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Suppressor of Cytokine Signaling 1 Protein MeSH Descriptor Data 2023


MeSH Heading
Suppressor of Cytokine Signaling 1 Protein
Tree Number(s)
D12.644.360.024.374.500
D12.776.157.057.249.500
D12.776.476.024.437.500
Unique ID
D000071222
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000071222
Scope Note
A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS1 functions as a negative regulator of CYTOKINES that signal through the JANUS KINASES-STAT 3 TRANSCRIPTION FACTOR (JAK/STAT3) pathway by inhibiting the activity of JANUS KINASES.
Entry Term(s)
SOCS1 Protein
Suppressor of Cytokine Signaling Protein 1 -
Registry Number
0
Previous Indexing
Carrier Proteins (1997-2016)
Intracellular Signaling Peptides and Proteins (2004-2016)
Repressor Proteins (2004-2016)
Suppressor of Cytokine Signaling Proteins (2006-2016)
Public MeSH Note
2017
History Note
2017
Date Established
2017/01/01
Date of Entry
2016/07/08
Revision Date
2016/04/15
Suppressor of Cytokine Signaling 1 Protein Preferred
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