NLM Logo

Suppressor of Cytokine Signaling 3 Protein MeSH Descriptor Data 2023


MeSH Heading
Suppressor of Cytokine Signaling 3 Protein
Tree Number(s)
D12.644.360.024.374.750
D12.776.157.057.249.750
D12.776.476.024.437.750
Unique ID
D000071223
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000071223
Scope Note
A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS3 inhibits cytokine signaling by binding to RECEPTOR PROTEIN-TYROSINE KINASES as well as CYTOKINE RECEPTOR GP130; ERYTHROPOIETIN RECEPTORS; INSULIN RECEPTOR; and the LEPTIN RECEPTOR. Its functions include suppression of ERYTHROPOIESIS in the fetal liver.
Entry Term(s)
SOCS3 Protein
Suppressor of Cytokine Signaling Protein 3
Registry Number
0
Previous Indexing
Repressor Proteins (1997-2016)
Suppressor of Cytokine Signaling Proteins (2006-2016)
Transcription Factors (1997-2016)
Public MeSH Note
2017
History Note
2017
Date Established
2017/01/01
Date of Entry
2016/07/08
Revision Date
2016/04/15
Suppressor of Cytokine Signaling 3 Protein Preferred
page delivered in 0.153s