MeSH Browser

MeSH Heading: Fibrillin-1
Tree Number(s): D09.400.430.800.500; D12.776.395.341.500; D12.776.860.300.400.500
Unique ID: D000071838
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000071838
Scope Note: A fibrillin (FBN1) that functions as a structural support protein for MICROFIBRILS. It also regulates the maturation of OSTEOBLASTS by controlling the availability and concentration of TGF-BETA and BONE MORPHOGENETIC PROTEINS. Mutations in the FBN1 gene are associated with MARFAN SYNDROME.
Entry Term(s): Profibrillin 1; Profibrillin-1
Public MeSH Note: 2017; see FIBRILLIN 1985-2016
History Note: 2017; use FIBRILLIN 1985-2016
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2023/03/16

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Fibrillin-1 MeSH Descriptor Data 2025