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Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases MeSH Descriptor Data 2023


MeSH Heading
Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases
Tree Number(s)
D08.811.277.352.650.624.750
Unique ID
D000072183
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000072183
Scope Note
Phosphoinositide phosphatases that catalyze the dephosphorylation (hydrolysis) of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) to produce PtdIns(3,4)P(2), which negatively regulates the PI3K ( 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASES) pathways. They contain an SH2 DOMAIN and STERILE ALPHA MOTIF and have important functions in regulating the immune response and other cellular processes in vertebrates.
Entry Term(s)
SHIP Phosphatases
Src Homology 2 Domain-Containing Inositol Phosphatases
Registry Number
EC 3.1.3.86
Previous Indexing
Phosphoric Monoester Hydrolases (1996-2016)
Public MeSH Note
2017
History Note
2017
Date Established
2017/01/01
Date of Entry
2016/07/08
Revision Date
2016/07/01
Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases Preferred
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