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A gap junction protein encoded by the Gap Junction Beta 2 or GJB2 gene. In the cochlea and epidermis, its hexamers form channels between cells that open to allow cell-to-cell diffusion of small molecules as well as recycling of potassium. Mutations in Connexin 26 are associated with congenital SENSORINEURAL HEARING LOSS.
Entry Term(s)
Connexin Cx26
Connexin beta-2
Gap Junction beta-2 protein
beta2 Connexin
Registry Numbers
127120-53-0
0
Public MeSH Note
2017; CONNEXIN 26 was indexed under CONNEXINS 1993-2016
A gap junction protein encoded by the Gap Junction Beta 2 or GJB2 gene. In the cochlea and epidermis, its hexamers form channels between cells that open to allow cell-to-cell diffusion of small molecules as well as recycling of potassium. Mutations in Connexin 26 are associated with congenital SENSORINEURAL HEARING LOSS.