MeSH Browser

MeSH Heading: SAM Domain and HD Domain-Containing Protein 1
Tree Number(s): D08.811.277.040.725; D08.811.277.352.700.843; D12.776.066.375
Unique ID: D000076106
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000076106
Scope Note: A host restriction triphosphorylhydrolase and dNTPase that contains an N-terminal STERILE ALPHA MOTIF and central, conserved ASPARTATE and HISTIDINE (HD) domain. It acts on single-stranded RNA, yielding deoxynucleosides and triphosphate, and functions in anti-viral defense through its dNTPase activity, reducing cellular dNTP levels below what is required for retroviral reverse transcription in DENDRITIC CELLS and MYELOID CELLS. It also has RIBONUCLEASE activity which blocks early replication of retroviruses such as HIV-1. Mutations in the SAMHD1 gene are associated with type 5 Aicardi-Goutieres syndrome (AGS5) and type 2 chilblain LUPUS (CHBL2).
Entry Term(s): SAMHD1 Deoxynucleoside Triphosphate Triphosphohydrolase; SAMHD1 Protein; SAMHD1 dNTPase
Related Numbers: EC 3.6.-
Previous Indexing: Monomeric GTP-Binding Proteins (2004-2017)
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2021/05/10

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000632192
Related Numbers: EC 3.6.-
Scope Note: A host restriction triphosphorylhydrolase and dNTPase that contains an N-terminal STERILE ALPHA MOTIF and central, conserved ASPARTATE and HISTIDINE (HD) domain. It acts on single-stranded RNA, yielding deoxynucleosides and triphosphate, and functions in anti-viral defense through its dNTPase activity, reducing cellular dNTP levels below what is required for retroviral reverse transcription in DENDRITIC CELLS and MYELOID CELLS. It also has RIBONUCLEASE activity which blocks early replication of retroviruses such as HIV-1. Mutations in the SAMHD1 gene are associated with type 5 Aicardi-Goutieres syndrome (AGS5) and type 2 chilblain LUPUS (CHBL2).
Terms: SAM Domain and HD Domain-Containing Protein 1 Preferred Term
Term UI T000925477
Date05/26/2017
LexicalTag NON
ThesaurusID NLM (2018); SAMHD1 Protein
Term UI T000925478
Date05/26/2017
LexicalTag ABX
ThesaurusID NLM (2018); SAMHD1 dNTPase
Term UI T000925479
Date05/26/2017
LexicalTag ABB
ThesaurusID NLM (2018); SAMHD1 Deoxynucleoside Triphosphate Triphosphohydrolase
Term UI T000925480
Date05/26/2017
LexicalTag ABX
ThesaurusID NLM (2018)

SAM Domain and HD Domain-Containing Protein 1 MeSH Descriptor Data 2025