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Tolcapone MeSH Descriptor Data 2023


MeSH Heading
Tolcapone
Tree Number(s)
D02.455.426.559.389.134.875
D02.455.426.559.389.657.566.845
D02.522.223.875
D02.640.743.845
Unique ID
D000077867
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000077867
Scope Note
A benzophenone and nitrophenol compound that acts as an inhibitor of CATECHOL O-METHYLTRANSFERASE, an enzyme involved in the metabolism of DOPAMINE and LEVODOPA. It is used in the treatment of PARKINSON DISEASE in patients for whom levodopa is ineffective or contraindicated.
Entry Term(s)
3,4-Dihydroxy-5'-methyl-5-nitrobenzophenone
Ro 40-7592
Ro-40-7592
SOM0226
Tasmar
Pharm Action
Antiparkinson Agents
Catechol O-Methyltransferase Inhibitors
Registry Number
CIF6334OLY
Related Numbers
134308-13-7
CAS Type 1 Name
Methanone, (3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)-
Public MeSH Note
2019; TOLCAPONE was indexed under BENZOPHENONES and NITROPHENOLS 1990-2018
History Note
2019 (1990)
Date Established
2019/01/01
Date of Entry
2018/07/09
Revision Date
2018/05/21
Tolcapone Preferred
3,4-Dihydroxy-5'-methyl-5-nitrobenzophenone Related
SOM0226 Narrower
Ro 40-7592 Narrower
Tasmar Narrower
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