A selective type of autophagy in which a specific set of cytosolic proteins are moved across the membrane of the LYSOSOMES by protein translocation, rather than by invagination of the lysosomal membrane. The proteins that will be degraded by chaperone-mediated autophagy (CMA) contain a CMA-targeting motif that, when exposed, is recognized by the cytosolic chaperone HSPA8 (aka Hsc70) and cochaperones which deliver the protein to LAMP2A monomers on the lysosome cell surface for translocation via the LAMP2A translocation complex. CMA is distinguished from CHAPERONE-ASSISTED-SELECTIVE AUTOPHAGY - a type of selective MACROAUTOPHAGY.
A selective type of autophagy in which a specific set of cytosolic proteins are moved across the membrane of the LYSOSOMES by protein translocation, rather than by invagination of the lysosomal membrane. The proteins that will be degraded by chaperone-mediated autophagy (CMA) contain a CMA-targeting motif that, when exposed, is recognized by the cytosolic chaperone HSPA8 (aka Hsc70) and cochaperones which deliver the protein to LAMP2A monomers on the lysosome cell surface for translocation via the LAMP2A translocation complex. CMA is distinguished from CHAPERONE-ASSISTED-SELECTIVE AUTOPHAGY - a type of selective MACROAUTOPHAGY.
