MeSH Browser

MeSH Heading: Piwi-Interacting RNA
Tree Number(s): D13.150.650.700.500; D13.444.735.150.700.500; D13.444.735.790.552.875.500
Unique ID: D000094322
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000094322
Scope Note: A class of small RNAs that are 24–31 nucleotides in length. They associate with the PIWI SUBFAMILY OF ARGONAUTE PROTEINS to form effector complexes known as piRNA-induced silencing complexes, which repress transposons via transcriptional or posttranscriptional mechanisms and maintain germline genome integrity. In addition to their role in transposon silencing, piRNAs in diverse organisms function in the regulation of cellular genes.
Entry Term(s): RNA, Piwi-Interacting; piRNA; piRNAs
Registry Numbers: 0
Previous Indexing: RNA, Small Interfering (2006-2022)
Public MeSH Note: 2023; see RNA,SMALL INTERFERING 2008-2022
History Note: 2023; use RNA,SMALL INTERFERING 2008-2022
Date Established: 2023/01/01
Date of Entry: 2022/07/11
Revision Date: 2022/07/11

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0507094
Registry Numbers: 0
Scope Note: A class of small RNAs that are 24–31 nucleotides in length. They associate with the PIWI SUBFAMILY OF ARGONAUTE PROTEINS to form effector complexes known as piRNA-induced silencing complexes, which repress transposons via transcriptional or posttranscriptional mechanisms and maintain germline genome integrity. In addition to their role in transposon silencing, piRNAs in diverse organisms function in the regulation of cellular genes.
Terms: Piwi-Interacting RNA Preferred Term
Term UI T692405
Date02/27/2007
LexicalTag ACX
ThesaurusID NLM (2008); piRNA
Term UI T768042
Date03/26/2010
LexicalTag ABB
ThesaurusID NLM (2011); RNA, Piwi-Interacting
Term UI T692410
Date02/27/2007
LexicalTag ACX
ThesaurusID NLM (2008); piRNAs
Term UI T001120153
Date04/28/2022
LexicalTag ABB
ThesaurusID NLM (2023)

Piwi-Interacting RNA MeSH Descriptor Data 2024