MeSH Browser

MeSH Heading: RNA, Small Interfering
Tree Number(s): D13.150.650.700; D13.444.735.150.700; D13.444.735.790.552.875
Unique ID: D034741
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D034741
Annotation: Do not confuse with defective interfering RNA (diRNA), a viral RNA of DEFECTIVE VIRUSES.
Scope Note: Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
Entry Term(s): RNA, Scan; Repeat-Associated siRNA; Scan RNA; Short Hairpin RNA; Short Interfering RNA; Small Hairpin RNA; Small Interfering RNA; Small Scan RNA; Trans-Acting siRNA; scnRNA; shRNA; siRNA; siRNA, Repeat-Associated; siRNA, Trans-Acting; tasiRNA
See Also: MicroRNAs; RNA Interference; RNA-Induced Silencing Complex
Public MeSH Note: 2003; RNA, SMALL INTERFERING was indexed under RNA, UNTRANSLATED 2001-2002
History Note: 2003; use RNA, SMALL INTERFERING (NM) 2001-2002
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2022/07/08

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Nucleic Acids, Nucleotides, and Nucleosides [D13]
- Antisense Elements (Genetics) [D13.150]
  - RNA, Antisense [D13.150.650]

Nucleic Acids, Nucleotides, and Nucleosides [D13]
- Nucleic Acids [D13.444]
  - RNA [D13.444.735]
    - RNA, Antisense [D13.444.735.150]

Nucleic Acids, Nucleotides, and Nucleosides [D13]
- Nucleic Acids [D13.444]
  - RNA [D13.444.735]
    - RNA, Untranslated [D13.444.735.790]
      - RNA, Small Untranslated [D13.444.735.790.552]
        
        MicroRNAs [D13.444.735.790.552.500]
        
        RNA, Guide, CRISPR-Cas Systems [D13.444.735.790.552.563]
        
        RNA, Guide, Kinetoplastida [D13.444.735.790.552.625]
        
        RNA, Small Cytoplasmic [D13.444.735.790.552.750]
        
        RNA, Small Interfering [D13.444.735.790.552.875]
        
        Piwi-Interacting RNA [D13.444.735.790.552.875.500]
        
        RNA, Small Nuclear [D13.444.735.790.552.937]
        
        RNA, Spliced Leader [D13.444.735.790.552.968]

RNA, Small Interfering Preferred

Concept UI: M0406100
Scope Note: Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
Terms: RNA, Small Interfering Preferred Term
Term UI T471901
Date12/03/2001
LexicalTag ACX
ThesaurusID NLM (2003); siRNA
Term UI T471902
Date12/03/2001
LexicalTag ACX
ThesaurusID NLM (2003); Small Interfering RNA
Term UI T765861
Date02/17/2010
LexicalTag NON
ThesaurusID NLM (2011); Short Interfering RNA
Term UI T773000
Date06/21/2010
LexicalTag NON
ThesaurusID NLM (2011)

Scan RNA Narrower

Concept UI: M0507095
Scope Note: siRNAs, found in TETRAHYMENA, that are homologous to internal eliminated sequences (IESs) deleted during programmed genome rearrangement.
Terms: Scan RNA Preferred Term
Term UI T692406
Date02/27/2007
LexicalTag ACX
ThesaurusID NLM (2008); RNA, Scan
Term UI T692412
Date02/27/2007
LexicalTag ACX
ThesaurusID NLM (2008); scnRNA
Term UI T693108
Date03/07/2007
LexicalTag ACX
ThesaurusID NLM (2008); Small Scan RNA
Term UI T692407
Date02/27/2007
LexicalTag ACX
ThesaurusID NLM (2008)

Repeat-Associated siRNA Related

Trans-Acting siRNA Narrower

Short Hairpin RNA Narrower

RNA, Small Interfering MeSH Descriptor Data 2025