MeSH Browser

MeSH Heading: RNA, Guide, CRISPR-Cas Systems
Tree Number(s): D13.444.735.790.552.563
Unique ID: D000094704
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000094704
Annotation: do not confuse with RNA, GUIDE, KINETOPLASTIDA; do not confuse sgRNA (SINGLE-GUIDE RNA) with sgRNA (SUBGENOMIC RNA)
Scope Note: A component of CRISPR-Cas SYSTEMS. Cas endodeoxyribonucleases assemble with a guide RNA complex, a hybrid of CRISPR RNA (crRNA) and transactivating crRNA (tracrRNA) molecules, to form an active complex that cleaves DNA. crRNA and tracrRNA can be synthetically fused into a single RNA molecule, namely single guide RNA. Synthetic sgRNA is used with CRISPR-Cas SYSTEMS for targeted GENE EDITING.
Entry Term(s): CRISPR Guide RNA; CRISPR-Cas Systems sgRNA (Single Guide RNA); Guide RNA (CRISPR-Cas Systems); Guide RNA, CRISPR-Cas Systems; RNA, CRISPR Guide; RNA, Guide (CRISPR-Cas Systems); RNA, Single Guide; RNA, Single-Guide; Single Guide RNA; Single-Guide RNA; Transactivating crRNA; crRNA; crRNA, Transactivating; sgRNA (CRISPR-Cas Systems); sgRNA (Single-Guide RNA); tracrRNA
Previous Indexing: CRISPR-Cas Systems (2014-2022); RNA, Guide, CRISPR-Cas Systems (2008-2022)
See Also: CRISPR-Cas Systems
Public MeSH Note: 2023
History Note: 2023
Date Established: 2023/01/01
Date of Entry: 2022/07/11
Revision Date: 2022/07/11

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000756254
Scope Note: A component of CRISPR-Cas SYSTEMS. Cas endodeoxyribonucleases assemble with a guide RNA complex, a hybrid of CRISPR RNA (crRNA) and transactivating crRNA (tracrRNA) molecules, to form an active complex that cleaves DNA. crRNA and tracrRNA can be synthetically fused into a single RNA molecule, namely single guide RNA. Synthetic sgRNA is used with CRISPR-Cas SYSTEMS for targeted GENE EDITING.
Terms: RNA, Guide, CRISPR-Cas Systems Preferred Term
Term UI T001120170
Date04/29/2022
LexicalTag NON
ThesaurusID NLM (2023); RNA, Guide (CRISPR-Cas Systems)
Term UI T001119936
Date04/15/2022
LexicalTag NON
ThesaurusID NLM (2023); Guide RNA, CRISPR-Cas Systems
Term UI T001120171
Date04/29/2022
LexicalTag NON
ThesaurusID NLM (2023); Guide RNA (CRISPR-Cas Systems)
Term UI T001119938
Date04/15/2022
LexicalTag NON
ThesaurusID NLM (2023)

Concept UI: M000756256
Terms: RNA, Single Guide Preferred Term
Term UI T001119923
Date04/15/2022
LexicalTag NON
ThesaurusID NLM (2023); sgRNA (Single-Guide RNA)
Term UI T001120173
Date04/29/2022
LexicalTag NON
ThesaurusID NLM (2023); CRISPR-Cas Systems sgRNA (Single Guide RNA)
Term UI T001120174
Date04/29/2022
LexicalTag NON
ThesaurusID NLM (2023); sgRNA (CRISPR-Cas Systems)
Term UI T001120009
Date04/21/2022
LexicalTag NON
ThesaurusID NLM (2023); RNA, Single-Guide
Term UI T001119924
Date04/15/2022
LexicalTag NON
ThesaurusID NLM (2023); Single Guide RNA
Term UI T001119925
Date04/15/2022
LexicalTag NON
ThesaurusID NLM (2023); Single-Guide RNA
Term UI T001119926
Date04/15/2022
LexicalTag NON
ThesaurusID NLM (2023)

RNA, Guide, CRISPR-Cas Systems MeSH Descriptor Data 2025