MeSH Browser

MeSH Heading: RNA Interference
Tree Number(s): G05.308.203.374.790
Unique ID: D034622
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D034622
Scope Note: A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
Entry Term(s): Co-Suppression; Cosuppression; Gene Silencing, Post-Transcriptional; Post-Transcriptional Gene Silencing; Posttranscriptional Gene Silencing; RNA Silencing; RNAi
NLM Classification #: QU 58.7
See Also: RNA-Induced Silencing Complex; RNA, Small Interfering; RNAi Therapeutics
Public MeSH Note: 2003
History Note: 2003
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2016/06/17

Allowable Qualifiers: drug effects (DE)

immunology (IM)

physiology (PH)

radiation effects (RE)

Concept UI: M0405879
Scope Note: A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
Terms: RNA Interference Preferred Term
Term UI T471539
Date11/29/2001
LexicalTag NON
ThesaurusID NLM (2003); Gene Silencing, Post-Transcriptional
Term UI T471584
Date11/30/2001
LexicalTag NON
ThesaurusID NLM (2003); RNA Silencing
Term UI T471541
Date11/29/2001
LexicalTag NON
ThesaurusID NLM (2003); Post-Transcriptional Gene Silencing
Term UI T471542
Date11/29/2001
LexicalTag NON
ThesaurusID NLM (2003); RNAi
Term UI T000870922
Date11/18/2014
LexicalTag ABB
ThesaurusID NLM (2016); Posttranscriptional Gene Silencing
Term UI T471540
Date11/29/2001
LexicalTag NON
ThesaurusID NLM (2003)

RNA Interference MeSH Descriptor Data 2023