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Degrons MeSH Descriptor Data 2024


MeSH Heading
Degrons
Tree Number(s)
G02.111.570.820.709.275.625
Unique ID
D000097791
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000097791
Scope Note
Minimal elements within a protein that are sufficient for recognition and degradation by a proteolytic apparatus. Inherent degrons are comprised of short linear amino acid sequences and secondary protein structural features that increase the affinity to E3 LIGASE; and are involved in regulating the specificity and timing of PROTEIN DEGRADATION. Acquired degrons are mostly transient and conferred by post-translational modifications of specific amino acids within proteins. (From Mol Cell. 2016 Sep 15;63(6):1055-65)
Entry Term(s)
C-Degrons
D-Box Motif
Destruction Box
Destruction Box Motif
Destruction Boxes
N-Degrons
PEST Motif
PEST Sequence
Public MeSH Note
2024
History Note
2024
Date Established
2024/01/01
Date of Entry
2023/07/26
Revision Date
2023/05/26
Degrons Preferred
Destruction Box Motif Narrower
PEST Motif Narrower
N-Degrons Narrower
C-Degrons Narrower
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