MeSH Browser

MeSH Heading: UGT1A1 Enzyme
Tree Number(s): D08.811.913.400.450.480.751
Unique ID: D000099148
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000099148
Scope Note: Glucuronosyltransferase encoded by UGT1 complex which encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini. It catalyzes reactions where lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility and excretion into either urine or bile. UGT1A1enzyme is essential for elimination and detoxification of drugs, xenobiotics and metabolites.
Entry Term(s): 1-Naphthol UDP-Glucuronosyltransferase; Bilirubin Uridine-Diphosphoglucuronosyl Transferase 1A1; Phenol GCStransferase; Phenol UDP-Glucuronosyltransferase; UDP Glucuronosyltransferase 1A1; UDP-Glucuronosyltransferase 1A1; UGT1A1 Protein
Registry Numbers: EC 2.4.1.17
Public MeSH Note: 2026 (2001)
History Note: 2026; UGT1A1 ENZYME was indexed under GLUCURONOSYLTRANSFERASE 2001-2026
Date Introduced: 2026/01/01
Last Updated: 2026/01/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Glycosyltransferases [D08.811.913.400]
      - Hexosyltransferases [D08.811.913.400.450]
        
        Glucuronosyltransferase [D08.811.913.400.450.480]
        
        Hyaluronan Synthases [D08.811.913.400.450.480.500]
        
        UDP-Glucuronosyltransferase 1A9 [D08.811.913.400.450.480.750]
        
        UGT1A1 Enzyme [D08.811.913.400.450.480.751]

UGT1A1 Enzyme Preferred

Concept UI: M000768753
Registry Numbers: EC 2.4.1.17
Scope Note: Glucuronosyltransferase encoded by UGT1 complex which encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini. It catalyzes reactions where lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility and excretion into either urine or bile. UGT1A1enzyme is essential for elimination and detoxification of drugs, xenobiotics and metabolites.
Terms: UGT1A1 Enzyme Preferred Term
Term UI T001147038
Date02/11/2025
LexicalTag NON
ThesaurusID NLM (2014); 1-Naphthol UDP-Glucuronosyltransferase
Term UI T001147039
Date02/11/2025
LexicalTag NON
ThesaurusID NLM (2026); Bilirubin Uridine-Diphosphoglucuronosyl Transferase 1A1
Term UI T001147044
Date02/11/2025
LexicalTag NON
ThesaurusID NLM (2001); Phenol GCStransferase
Term UI T001147041
Date02/11/2025
LexicalTag NON
ThesaurusID NLM (2014); Phenol UDP-Glucuronosyltransferase
Term UI T001147042
Date02/11/2025
LexicalTag NON
ThesaurusID NLM (2014); UDP Glucuronosyltransferase 1A1
Term UI T001147043
Date02/11/2025
LexicalTag NON
ThesaurusID NLM (2001); UDP-Glucuronosyltransferase 1A1
Term UI T001147045
Date02/11/2025
LexicalTag NON
ThesaurusID NLM (2005); UGT1A1 Protein
Term UI T001147037
Date02/11/2025
LexicalTag NON
ThesaurusID NLM (2026)

UGT1A1 Enzyme MeSH Descriptor Data 2026