MeSH Browser

MeSH Heading: Glucuronosyltransferase
Tree Number(s): D08.811.913.400.450.480
Unique ID: D014453
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D014453
Annotation: /defic: consider also CRIGLER-NAJJAR SYNDROME & coord with BILIRUBIN /‌metab (NIM)
Scope Note: A family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines, and fatty acids. They function as drug-metabolizing enzymes that catalyze the conjugation of UDPglucuronic acid to a variety of endogenous and exogenous compounds. EC 2.4.1.17.
Entry Term(s): 17 beta-Hydroxysteroid UDP-Glucuronosyltransferase; 4-Nitrophenol-UDP-Glucuronosyltransferase; 7-Hydroxycoumarin UDP Glucuronyltransferase; Androsterone UDP-Glucuronosyltransferase; Bilirubin UDP-Glucuronyltransferase; Estrogen UDP-Glucuronosyltransferase; Estrone Glucuronyltransferase; Glucuronic Transferase; Glucuronyltransferase; Morphine Glucuronyltransferase; UDP Glucuronosyltransferase; UDP Glucuronyl Transferase; UDP-Glucuronic Acid 3-O-beta-D-Galactosyl-D-Galactose Glucuronosyltransferase; p-Nitrophenyl UDP-Glucuronosyltransferase
Registry Number: EC 2.4.1.17
Related Numbers: 9030-08-4
CAS Type 1 Name: UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)
Previous Indexing: Hexosyltransferases (1972-1973); Transferases (1966-1971)
Public MeSH Note: 92; was UDP GLUCURONOSYLTRANSFERASE 1975-91 (see under HEXOSYLTRANSFERASES 1975-76)
Online Note: use GLUCURONOSYLTRANSFERASE to search UDP GLUCURONOSYLTRANSFERASE 1973-91 (as Prov 1973-74)
History Note: 92; was UDP GLUCURONOSYLTRANSFERASE 1973-91 (see under HEXOSYLTRANSFERASES 1975-76, Prov 1973-74)
Date Established: 1977/01/01
Date of Entry: 1999/01/01
Revision Date: 2003/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Glycosyltransferases [D08.811.913.400]
      - Hexosyltransferases [D08.811.913.400.450]
        
        Fucosyltransferases [D08.811.913.400.450.300]
        
        Galactosyltransferases [D08.811.913.400.450.400]
        
        Glucosyltransferases [D08.811.913.400.450.460]
        
        Glucuronosyltransferase [D08.811.913.400.450.480]
        
        Hyaluronan Synthases [D08.811.913.400.450.480.500]
        
        UDP-Glucuronosyltransferase 1A9 [D08.811.913.400.450.480.750]
        
        Mannosyltransferases [D08.811.913.400.450.560]
        
        Peptidoglycan Glycosyltransferase [D08.811.913.400.450.780]

Glucuronosyltransferase Preferred

Concept UI: M0022213
Registry Number: EC 2.4.1.17
Related Numbers: 9030-08-4
Scope Note: A family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines, and fatty acids. They function as drug-metabolizing enzymes that catalyze the conjugation of UDPglucuronic acid to a variety of endogenous and exogenous compounds. EC 2.4.1.17.
Terms: Glucuronosyltransferase Preferred Term
Term UI T042287
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1975); Glucuronyltransferase
Term UI T042290
Date04/25/1977
LexicalTag NON
ThesaurusID UNK (19XX); UDP Glucuronyl Transferase
Term UI T042289
Date12/09/1981
LexicalTag NON
ThesaurusID UNK (19XX); Glucuronic Transferase
Term UI T042286
Date08/08/1988
LexicalTag NON
ThesaurusID UNK (19XX); UDP Glucuronosyltransferase
Term UI T042288
Date02/12/1991
LexicalTag NON
ThesaurusID NLM (1992)

4-Nitrophenol-UDP-Glucuronosyltransferase Narrower

7-Hydroxycoumarin UDP Glucuronyltransferase Narrower

Androsterone UDP-Glucuronosyltransferase Narrower

p-Nitrophenyl UDP-Glucuronosyltransferase Narrower

Estrogen UDP-Glucuronosyltransferase Narrower

Estrone Glucuronyltransferase Narrower

UDP-Glucuronic Acid 3-O-beta-D-Galactosyl-D-Galactose Glucuronosyltransferase Related

Morphine Glucuronyltransferase Narrower

17 beta-Hydroxysteroid UDP-Glucuronosyltransferase Narrower

Bilirubin UDP-Glucuronyltransferase Narrower

Glucuronosyltransferase MeSH Descriptor Data 2023