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Buprenorphine MeSH Descriptor Data 2021


MeSH Heading
Buprenorphine
Tree Number(s)
D03.132.577.249.150
D03.605.497.150
D03.633.400.686.150
D04.615.723.795.150
Unique ID
D002047
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D002047
Annotation
for buprenorphine maintenance treatment, coordinate with OPIATE SUBSTITUTION TREATMENT
Scope Note
A derivative of the opioid alkaloid THEBAINE that is a more potent and longer lasting analgesic than MORPHINE. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use.
Entry Term(s)
6029-M
Buprenex
Buprenorphine Hydrochloride
Buprex
Prefin
RX-6029-M
Subutex
Temgesic
Temgésic
Pharm Action
Analgesics, Opioid
Narcotic Antagonists
Narcotics
Registry Number
40D3SCR4GZ
Related Numbers
52485-79-7
53152-21-9
56W8MW3EN1
CAS Type 1 Name
6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-, (5alpha,7alpha(S))-
NLM Classification #
QV 92
Previous Indexing
Dihydromorphinone (1966-1968)
Morphinans (1969-1978)
Morphine (1966-1968)
See Also
Opiate Substitution Treatment
Public MeSH Note
87; was see under MORPHINANS 1979-86
History Note
87(79); was see under MORPHINANS 1979-86
Date Established
1987/01/01
Date of Entry
1978/03/17
Revision Date
2017/05/24
Buprenorphine Preferred
Buprenex Narrower
Prefin Narrower
Subutex Narrower
6029-M Narrower
Buprenorphine Hydrochloride Narrower
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