MeSH Browser

MeSH Heading: Charcot-Marie-Tooth Disease
Tree Number(s): C10.500.300.200; C10.574.500.495.200; C10.668.829.800.300.200; C16.131.666.300.200; C16.320.400.375.200
Unique ID: D002607
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D002607
Scope Note: A hereditary motor and sensory neuropathy transmitted most often as an autosomal dominant trait and characterized by progressive distal wasting and loss of reflexes in the muscles of the legs (and occasionally involving the arms). Onset is usually in the second to fourth decade of life. This condition has been divided into two subtypes, hereditary motor and sensory neuropathy (HMSN) types I and II. HMSN I is associated with abnormal nerve conduction velocities and nerve hypertrophy, features not seen in HMSN II. (Adams et al., Principles of Neurology, 6th ed, p1343)
Entry Version: CHARCOT MARIE TOOTH DIS
Entry Term(s): Atrophy, Muscular, Peroneal; Charcot-Marie Disease; Charcot-Marie-Tooth Disease, Autosomal Dominant, With Focally Folded Myelin Sheaths, Type 1A; Charcot-Marie-Tooth Disease, Autosomal Dominant, with Focally Folded Myelin Sheaths, Type 1B; Charcot-Marie-Tooth Disease, Demyelinating, Type 1A; Charcot-Marie-Tooth Disease, Demyelinating, Type 1B; Charcot-Marie-Tooth Disease, Slow Nerve Conduction Type, Linked To Duffy; Charcot-Marie-Tooth Disease, Type 1A; Charcot-Marie-Tooth Disease, Type 1B; Charcot-Marie-Tooth Disease, Type I; Charcot-Marie-Tooth Disease, Type IA; Charcot-Marie-Tooth Disease, Type IB; Charcot-Marie-Tooth Disease, Type II; Charcot-Marie-Tooth Hereditary Neuropathy; Charcot-Marie-Tooth Neuropathy, Type 1A; Charcot-Marie-Tooth Neuropathy, Type 1B; Charcot-Marie-Tooth Syndrome; HMN Distal Type I; HMSN 1A; HMSN 1B; HMSN I; HMSN IA; HMSN IB; HMSN II; HMSN Type I; HMSN Type II; HMSN1A; HMSN1B; Hereditary Areflexic Dystasia; Hereditary Motor And Sensory Neuropathy IB; Hereditary Motor and Sensory Neuropathy 1A; Hereditary Motor and Sensory Neuropathy 1B; Hereditary Motor and Sensory Neuropathy IA; Hereditary Motor and Sensory-Neuropathy Type II; Hereditary Motor, and Sensory Neuropathy Type I; Hereditary Type I Motor and Sensory Neuropathy; Muscular Atrophy, Peroneal; Neuropathy, Type I Hereditary Motor and Sensory; Neuropathy, Type II Hereditary Motor and Sensory; Peroneal Muscular Atrophy; Roussy Levy Hereditary Areflexic Dystasia; Roussy-Levy Disease; Roussy-Levy Hereditary Areflexic Dystasia; Roussy-Levy Syndrome
NLM Classification #: WE 550
See Also: Myelin P0 Protein
Public MeSH Note: 2000; see CHARCOT-MARIE DISEASE 1991-1999, see MUSCULAR ATROPHY, SPINAL 1988-1990, see MUSCULAR ATROPHY 1966-1987; for CHARCOT-MARIE-TOOTH DISEASE see CHARCOT-MARIE DISEASE 1991-1999
History Note: 2000(1966)
Date Established: 1991/01/01
Date of Entry: 1999/11/08
Revision Date: 2013/07/08

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Nervous System Diseases [C10]
- Nervous System Malformations [C10.500]
  - Hereditary Sensory and Motor Neuropathy [C10.500.300]

Nervous System Diseases [C10]
- Neurodegenerative Diseases [C10.574]
  - Heredodegenerative Disorders, Nervous System [C10.574.500]
    - Hereditary Sensory and Motor Neuropathy [C10.574.500.495]

Nervous System Diseases [C10]
- Neuromuscular Diseases [C10.668]
  - Peripheral Nervous System Diseases [C10.668.829]
    - Polyneuropathies [C10.668.829.800]
      - Hereditary Sensory and Motor Neuropathy [C10.668.829.800.300]
        
        Alstrom Syndrome [C10.668.829.800.300.099]
        
        Charcot-Marie-Tooth Disease [C10.668.829.800.300.200]
        
        Giant Axonal Neuropathy [C10.668.829.800.300.490]
        
        Refsum Disease [C10.668.829.800.300.780]
        
        Spastic Paraplegia, Hereditary [C10.668.829.800.300.820]

Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Congenital Abnormalities [C16.131]
  - Nervous System Malformations [C16.131.666]
    - Hereditary Sensory and Motor Neuropathy [C16.131.666.300]

Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
  - Heredodegenerative Disorders, Nervous System [C16.320.400]
    - Hereditary Sensory and Motor Neuropathy [C16.320.400.375]

Charcot-Marie-Tooth Disease Preferred

Concept UI: M0003994
Scope Note: A hereditary motor and sensory neuropathy transmitted most often as an autosomal dominant trait and characterized by progressive distal wasting and loss of reflexes in the muscles of the legs (and occasionally involving the arms). Onset is usually in the second to fourth decade of life. This condition has been divided into two subtypes, hereditary motor and sensory neuropathy (HMSN) types I and II. HMSN I is associated with abnormal nerve conduction velocities and nerve hypertrophy, features not seen in HMSN II. (Adams et al., Principles of Neurology, 6th ed, p1343)
Terms: Charcot-Marie-Tooth Disease Preferred Term
Term UI T007590
Date06/07/1988
LexicalTag EPO
ThesaurusID; Muscular Atrophy, Peroneal
Term UI T371955
Date11/08/1999
LexicalTag NON
ThesaurusID NLM (2000); Peroneal Muscular Atrophy
Term UI T371956
Date11/08/1999
LexicalTag NON
ThesaurusID; Charcot-Marie-Tooth Syndrome
Term UI T841102
Date04/18/2013
LexicalTag EPO
ThesaurusID; Atrophy, Muscular, Peroneal
Term UI T371952
Date11/08/1999
LexicalTag NON
ThesaurusID NLM (2000); Charcot-Marie Disease
Term UI T007589
Date01/01/1999
LexicalTag EPO
ThesaurusID NLM (1975); Charcot-Marie-Tooth Hereditary Neuropathy
Term UI T841101
Date04/18/2013
LexicalTag EPO
ThesaurusID

Roussy-Levy Syndrome Related

HMSN Type II Narrower

Hereditary Type I Motor and Sensory Neuropathy Narrower

Charcot-Marie-Tooth Disease, Type IA Narrower

Charcot-Marie-Tooth Disease, Type IB Narrower

Charcot-Marie-Tooth Disease MeSH Descriptor Data 2025