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Spastic Paraplegia, Hereditary MeSH Descriptor Data 2021


MeSH Heading
Spastic Paraplegia, Hereditary
Tree Number(s)
C10.500.300.820
C10.574.500.495.820
C10.668.829.800.300.820
C16.131.666.300.820
C16.320.400.375.820
Unique ID
D015419
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D015419
Annotation
coordinate with GENES, DOMINANT or GENES, RECESSIVE if discussed
Scope Note
A group of inherited diseases that share similar phenotypes but are genetically diverse. Different genetic loci for autosomal recessive, autosomal dominant, and x-linked forms of hereditary spastic paraplegia have been identified. Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. Peripheral sensory neurons may be affected in the later stages of the disease. (J Neurol Neurosurg Psychiatry 1998 Jan;64(1):61-6; Curr Opin Neurol 1997 Aug;10(4):313-8)
Entry Term(s)
Autosomal Dominant Hereditary Spastic Paraplegia
Autosomal Dominant Spastic Paraplegia Hereditary
Autosomal Recessive Hereditary Spastic Paraplegia
Autosomal Recessive Spastic Paraplegia, Hereditary
CMT with Pyramidal Features
Charcot-Marie-Tooth Disease with Pyramidal Features, Autosomal Dominant
HMSN 5
HMSN Type V
HMSN V
HMSN V (Hereditary Motor and Sensory Neuropathy Type V)
Hereditary Autosomal Dominant Spastic Paraplegia
Hereditary Autosomal Recessive Spastic Paraplegia
Hereditary Motor And Sensory Neuropathy V
Hereditary Motor and Sensory Neuropathy 5
Hereditary Motor-Sensory Neuropathy with Pyramidal Signs
Hereditary Spastic Paraplegia
Hereditary Spastic Paraplegia, Autosomal Recessive
Hereditary X-Linked Recessive Spastic Paraplegia
Hereditary, Spastic Paraplegia, Autosomal Dominant
Hereditary, Spastic Paraplegia, X-Linked Recessive
Hypertrophic Motor-Sensory Neuropathy-Spastic Paraplegia
Paraplegia, Spastic, Hereditary
Peroneal Muscular Atrophy with Pyramidal Features, Autosomal Dominant
Spastic Paraplegia 2
Spastic Paraplegia Type 2
Spastic Paraplegia, Autosomal Dominant, Hereditary
Spastic Paraplegia, Autosomal Recessive, Hereditary
Spastic Paraplegia, Hereditary, Autosomal Dominant
Spastic Paraplegia, Hereditary, Autosomal Recessive
Spastic Paraplegia, Hereditary, X-Linked Recessive
Spastic Paraplegia, X-Linked Recessive, Hereditary
Spastic Paraplegia-Hypertrophic Motor-Sensory Neuropathy
Type V Hereditary Motor and Sensory Neuropathy
X Linked Recessive Hereditary Spastic Paraplegia
X-Linked, Spastic Paraplegia, Hereditary
X-linked Recessive Hereditary Spastic Paraplegia
Previous Indexing
Muscle Spasticity/genetics (1975-1988)
Paraplegia/genetics (1966-1988)
Public MeSH Note
1991; see NEUROPATHIES, HEREDITARY MOTOR AND SENSORY 1989-1990
History Note
1991(1989)
Date Established
1991/01/01
Date of Entry
1988/06/07
Revision Date
2019/05/21
Spastic Paraplegia, Hereditary Preferred
X-Linked, Spastic Paraplegia, Hereditary Narrower
Hereditary Autosomal Dominant Spastic Paraplegia Narrower
Hereditary X-Linked Recessive Spastic Paraplegia Narrower
Hereditary Motor-Sensory Neuropathy with Pyramidal Signs Narrower
Autosomal Recessive Hereditary Spastic Paraplegia Narrower
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