MeSH Browser

MeSH Heading: Spastic Paraplegia, Hereditary
Tree Number(s): C10.500.300.820; C10.574.500.495.820; C10.668.829.800.300.820; C16.131.666.300.820; C16.320.400.375.820
Unique ID: D015419
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015419
Annotation: coordinate with GENES, DOMINANT or GENES, RECESSIVE if discussed
Scope Note: A group of inherited diseases that share similar phenotypes but are genetically diverse. Different genetic loci for autosomal recessive, autosomal dominant, and x-linked forms of hereditary spastic paraplegia have been identified. Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. Peripheral sensory neurons may be affected in the later stages of the disease. (J Neurol Neurosurg Psychiatry 1998 Jan;64(1):61-6; Curr Opin Neurol 1997 Aug;10(4):313-8)
Entry Term(s): Autosomal Dominant Hereditary Spastic Paraplegia; Autosomal Dominant Spastic Paraplegia Hereditary; Autosomal Recessive Hereditary Spastic Paraplegia; Autosomal Recessive Spastic Paraplegia, Hereditary; CMT with Pyramidal Features; Charcot-Marie-Tooth Disease with Pyramidal Features, Autosomal Dominant; HMSN 5; HMSN Type V; HMSN V; HMSN V (Hereditary Motor and Sensory Neuropathy Type V); Hereditary Autosomal Dominant Spastic Paraplegia; Hereditary Autosomal Recessive Spastic Paraplegia; Hereditary Motor And Sensory Neuropathy V; Hereditary Motor and Sensory Neuropathy 5; Hereditary Motor-Sensory Neuropathy with Pyramidal Signs; Hereditary Spastic Paraplegia; Hereditary Spastic Paraplegia, Autosomal Recessive; Hereditary X-Linked Recessive Spastic Paraplegia; Hereditary, Spastic Paraplegia, Autosomal Dominant; Hereditary, Spastic Paraplegia, X-Linked Recessive; Hypertrophic Motor-Sensory Neuropathy-Spastic Paraplegia; Paraplegia, Spastic, Hereditary; Peroneal Muscular Atrophy with Pyramidal Features, Autosomal Dominant; Spastic Paraplegia 2; Spastic Paraplegia Type 2; Spastic Paraplegia, Autosomal Dominant, Hereditary; Spastic Paraplegia, Autosomal Recessive, Hereditary; Spastic Paraplegia, Hereditary, Autosomal Dominant; Spastic Paraplegia, Hereditary, Autosomal Recessive; Spastic Paraplegia, Hereditary, X-Linked Recessive; Spastic Paraplegia, X-Linked Recessive, Hereditary; Spastic Paraplegia-Hypertrophic Motor-Sensory Neuropathy; Type V Hereditary Motor and Sensory Neuropathy; X Linked Recessive Hereditary Spastic Paraplegia; X-Linked, Spastic Paraplegia, Hereditary; X-linked Recessive Hereditary Spastic Paraplegia
NLM Classification #: WE 550
Previous Indexing: Muscle Spasticity/genetics (1975-1988); Paraplegia/genetics (1966-1988)
Public MeSH Note: 1991; see NEUROPATHIES, HEREDITARY MOTOR AND SENSORY 1989-1990
History Note: 1991(1989)
Date Established: 1991/01/01
Date of Entry: 1988/06/07
Revision Date: 2019/05/21

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Nervous System Diseases [C10]
- Nervous System Malformations [C10.500]
  - Hereditary Sensory and Motor Neuropathy [C10.500.300]

Nervous System Diseases [C10]
- Neurodegenerative Diseases [C10.574]
  - Heredodegenerative Disorders, Nervous System [C10.574.500]
    - Hereditary Sensory and Motor Neuropathy [C10.574.500.495]

Nervous System Diseases [C10]
- Neuromuscular Diseases [C10.668]
  - Peripheral Nervous System Diseases [C10.668.829]
    - Polyneuropathies [C10.668.829.800]
      - Hereditary Sensory and Motor Neuropathy [C10.668.829.800.300]
        
        Alstrom Syndrome [C10.668.829.800.300.099]
        
        Charcot-Marie-Tooth Disease [C10.668.829.800.300.200]
        
        Giant Axonal Neuropathy [C10.668.829.800.300.490]
        
        Refsum Disease [C10.668.829.800.300.780]
        
        Spastic Paraplegia, Hereditary [C10.668.829.800.300.820]

Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Congenital Abnormalities [C16.131]
  - Nervous System Malformations [C16.131.666]
    - Hereditary Sensory and Motor Neuropathy [C16.131.666.300]

Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
  - Heredodegenerative Disorders, Nervous System [C16.320.400]
    - Hereditary Sensory and Motor Neuropathy [C16.320.400.375]

Spastic Paraplegia, Hereditary Preferred

Concept UI: M0023769
Scope Note: A group of inherited diseases that share similar phenotypes but are genetically diverse. Different genetic loci for autosomal recessive, autosomal dominant, and x-linked forms of hereditary spastic paraplegia have been identified. Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. Peripheral sensory neurons may be affected in the later stages of the disease. (J Neurol Neurosurg Psychiatry 1998 Jan;64(1):61-6; Curr Opin Neurol 1997 Aug;10(4):313-8)
Terms: Spastic Paraplegia, Hereditary Preferred Term
Term UI T045537
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1989); Paraplegia, Spastic, Hereditary
Term UI T045536
Date06/07/1988
LexicalTag NON
ThesaurusID UNK (19XX); Spastic Paraplegia-Hypertrophic Motor-Sensory Neuropathy
Term UI T371545
Date11/03/1999
LexicalTag NON
ThesaurusID NLM (2000); Hypertrophic Motor-Sensory Neuropathy-Spastic Paraplegia
Term UI T371540
Date11/03/1999
LexicalTag NON
ThesaurusID NLM (2000); Hereditary Spastic Paraplegia
Term UI T045535
Date06/07/1988
LexicalTag NON
ThesaurusID UNK (19XX)

X-Linked, Spastic Paraplegia, Hereditary Narrower

Hereditary Autosomal Dominant Spastic Paraplegia Narrower

Hereditary X-Linked Recessive Spastic Paraplegia Narrower

Hereditary Motor-Sensory Neuropathy with Pyramidal Signs Narrower

Autosomal Recessive Hereditary Spastic Paraplegia Narrower

Spastic Paraplegia, Hereditary MeSH Descriptor Data 2023