MeSH Browser

MeSH Heading: Cross-Linking Reagents
Tree Number(s): D27.720.470.410.210
Unique ID: D003432
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D003432
Scope Note: Reagents with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between side chains of amino acids in proteins; the locations of naturally reactive areas within proteins can thereby be identified; may also be used for other macromolecules, like glycoproteins, nucleic acids, or other.
Entry Term(s): Bifunctional Reagent; Bifunctional Reagents; Cross Linking Reagent; Cross Linking Reagents; Crosslinking Reagent; Crosslinking Reagents
Previous Indexing: Indicators and Reagents (1966-1979); Protein Binding (1966-1979)
Public MeSH Note: 80
History Note: 80
Date Established: 1980/01/01
Date of Entry: 1979/03/01
Revision Date: 2021/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

Concept UI: M0005349
Scope Note: Reagents with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between side chains of amino acids in proteins; the locations of naturally reactive areas within proteins can thereby be identified; may also be used for other macromolecules, like glycoproteins, nucleic acids, or other.
Terms: Cross-Linking Reagents Preferred Term
Term UI T009991
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1980); Bifunctional Reagents
Term UI T009989
Date03/01/1979
LexicalTag NON
ThesaurusID UNK (19XX); Cross Linking Reagents
Term UI T009990
Date03/01/1979
LexicalTag NON
ThesaurusID UNK (19XX); Crosslinking Reagents
Term UI T009992
Date03/01/1979
LexicalTag NON
ThesaurusID UNK (19XX); Cross Linking Reagent
Term UI T001089768
Date10/13/2020
LexicalTag NON
ThesaurusID NLM (2022); Crosslinking Reagent
Term UI T001089769
Date10/13/2020
LexicalTag NON
ThesaurusID NLM (2022); Bifunctional Reagent
Term UI T001089770
Date10/13/2020
LexicalTag NON
ThesaurusID NLM (2022)

Cross-Linking Reagents MeSH Descriptor Data 2025