MeSH Browser

MeSH Heading: Proteolysis Targeting Chimera
Tree Number(s): D27.720.470.410.210.500
Unique ID: D000094243
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000094243
Scope Note: Bifunctional molecules that are designed to recruit E3 UBIQUITIN LIGASE to a specific target protein. Proteolysis targeting chimera consist of a target protein ligand connected via a linker to an E3 ligand. They promote association of E3 with specific target proteins tagged for degradation via the PROTEASOME.
Entry Term(s): Cereblon-Based Small-Molecule Compounds; IAP-Based PROTACs; MDM2 Protein-Based PROTACs; PROTAC Proteolysis Targeting Chimera; PROTACs; Phospho-Dependent PROTACs; PhosphoPROTACs; Proteolysis Targeting Chimeras; VHL-Based PROTACs
Previous Indexing: Proteolysis (2015-2022)
Public MeSH Note: 2023
History Note: 2023
Date Established: 2023/01/01
Date of Entry: 2022/07/08
Revision Date: 2023/04/05

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

Concept UI: M000755726
Scope Note: Bifunctional molecules that are designed to recruit E3 UBIQUITIN LIGASE to a specific target protein. Proteolysis targeting chimera consist of a target protein ligand connected via a linker to an E3 ligand. They promote association of E3 with specific target proteins tagged for degradation via the PROTEASOME.
Terms: Proteolysis Targeting Chimera Preferred Term
Term UI T001118809
Date03/15/2022
LexicalTag NON
ThesaurusID NLM (2023); PROTACs
Term UI T001118810
Date03/15/2022
LexicalTag ACR
ThesaurusID NLM (2023); PROTAC Proteolysis Targeting Chimera
Term UI T001132916
Date02/15/2023
LexicalTag ACX
ThesaurusID NLM (2024); Proteolysis Targeting Chimeras
Term UI T001132945
Date02/15/2023
LexicalTag NON
ThesaurusID NLM (2024)

Proteolysis Targeting Chimera MeSH Descriptor Data 2025