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Glutamate-Cysteine Ligase MeSH Descriptor Data 2026
One of the enzymes active in the gamma-glutamyl cycle. It catalyzes the synthesis of gamma-glutamylcysteine from glutamate and cysteine in the presence of ATP with the formation of ADP and orthophosphate. EC 6.3.2.2.
Entry Term(s)
Glutamylcysteine Synthetase
gamma-Glutamyl-Cysteine Synthetase
Registry Numbers
EC 6.3.2.2
Related Numbers
9023-64-7
CAS Type 1 Name
L-Glutamate:L-cysteine gamma-ligase (ADP-forming)
Previous Indexing
Cysteine (1973-1976)
Glutamates (1973-1976)
Peptide Synthetases (1973-1976)
Public MeSH Note
98; see GAMMA-GLUTAMYL-CYSTEINE SYNTHETASE 1991-97; see PEPTIDE SYNTHETASES 1977-90
One of the enzymes active in the gamma-glutamyl cycle. It catalyzes the synthesis of gamma-glutamylcysteine from glutamate and cysteine in the presence of ATP with the formation of ADP and orthophosphate. EC 6.3.2.2.