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Gonadal Dysgenesis, 46,XY MeSH Descriptor Data 2022


MeSH Heading
Gonadal Dysgenesis, 46,XY
Tree Number(s)
C12.050.351.875.253.096.687
C12.050.351.875.253.309.388
C12.200.706.316.096.687
C12.200.706.316.309.388
C12.800.316.096.687
C12.800.316.309.388
C16.131.939.316.096.687
C16.131.939.316.309.388
C19.391.119.096.687
C19.391.119.309.388
Unique ID
D006061
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D006061
Scope Note
Defects in the SEX DETERMINATION PROCESS in 46, XY individuals that result in abnormal gonadal development and deficiencies in TESTOSTERONE and subsequently ANTIMULLERIAN HORMONE or other factors required for normal male sex development. This leads to the development of female phenotypes (male to female sex reversal), normal to tall stature, and bilateral streak or dysgenic gonads which are susceptible to GONADAL TISSUE NEOPLASMS. An XY gonadal dysgenesis is associated with structural abnormalities on the Y CHROMOSOME, a mutation in the GENE, SRY, or a mutation in other autosomal genes that are involved in sex determination.
Entry Term(s)
46, XY Gonadal Dysgenesis
46, XY Gonadal Sex Reversal
46,XY Complete Gonadal Dysgenesis
Complete Gonadal Dysgenesis, 46, XY
Gonadal Dysgenesis, 46, XY
Pure Gonadal Dysgenesis 46,XY
Pure Gonadal Dysgenesis, 46, XY
Sex Reversal, Gonadal, 46, XY
Swyer Syndrome
XY Pure Gonadal Dysgenesis
Previous Indexing
Sex Differentiation Disorders (1966-1979)
Turner's Syndrome (1967-1979)
Public MeSH Note
91; was see under GONADAL DYSGENESIS 1980-90
History Note
91(80); was see under GONADAL DYSGENESIS 1980-90
Date Established
1991/01/01
Date of Entry
1978/12/21
Revision Date
2021/06/30
Gonadal Dysgenesis, 46,XY Preferred
Swyer Syndrome Narrower
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