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GTP Cyclohydrolase MeSH Descriptor Data 2023


MeSH Heading
GTP Cyclohydrolase
Tree Number(s)
D08.811.277.151.300
Unique ID
D006136
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D006136
Scope Note
(GTP cyclohydrolase I) or GTP 7,8-8,9-dihydrolase (pyrophosphate-forming) (GTP cyclohydrolase II). An enzyme group that hydrolyzes the imidazole ring of GTP, releasing carbon-8 as formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized. This is the first step in the synthesis of folic acid from GTP. EC 3.5.4.16 (GTP cyclohydrolase I) and EC 3.5.4.25 (GTP cyclohydrolase II).
Entry Term(s)
7,8-Dihydroneopterintriphosphate Synthetase
GTP 8-Formylhydrolase
GTP Cyclohydrolase I
GTP Cyclohydrolase II
GTP Dihydrolase
GTP Ring-Opening Enzyme
Registry Number
EC 3.5.4.16
CAS Type 1 Name
GTP 7,8-8,9-dihydrolase
Previous Indexing
Aminohydrolases (1974)
Guanosine Triphosphate (1974)
Public MeSH Note
91; was see under AMINOHYDROLASES 1975-90
History Note
91(75); was see under AMINOHYDROLASES 1975-90
Date Established
1991/01/01
Date of Entry
1974/11/19
Revision Date
2003/07/09
GTP Cyclohydrolase Preferred
GTP Cyclohydrolase II Narrower
GTP Cyclohydrolase I Narrower
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