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Insulin, Isophane MeSH Descriptor Data 2023


MeSH Heading
Insulin, Isophane
Tree Number(s)
D06.472.699.587.200.300.200
D12.644.548.586.200.300.200
Unique ID
D007336
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D007336
Scope Note
An intermediate-acting INSULIN preparation with onset time of 2 hours and duration of 24 hours. It is produced by crystallizing ZINC-insulin-PROTAMINES at neutral pH 7. Thus it is called neutral protamine Hagedorn for inventor Hans Christian Hagedorn.
Entry Term(s)
Insulin, NPH
Insulin, Protamine Zinc
Isophane Insulin, Regular
NPH Insulin
Neutral Protamine Hagedorn Insulin
Protamine Hagedorn Insulin
Pharm Action
Hypoglycemic Agents
Registry Number
53027-39-7
CAS Type 1 Name
Insulin Isophane
Public MeSH Note
2009; see INSULIN, NPH 2009-2011; see INSULIN, ISOPHANE 1963-2008; for INSULIN, PROTAMINE ZINC see INSULIN, LONG-ACTING 1966-2011
History Note
2009 (1963); for INSULIN, PROTAMINE ZINC use INSULIN, LONG-ACTING 1966-2011
Entry Combination
antagonists & inhibitors:Insulin Antagonists
Date Established
2009/01/01
Date of Entry
1999/01/01
Revision Date
2015/05/26
Insulin, Isophane Preferred
Insulin, Protamine Zinc Related
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