MeSH Browser

MeSH Heading: Insulin, Isophane
Tree Number(s): D06.472.699.587.200.300.200; D12.644.548.586.200.300.200
Unique ID: D007336
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D007336
Scope Note: An intermediate-acting INSULIN preparation with onset time of 2 hours and duration of 24 hours. It is produced by crystallizing ZINC-insulin-PROTAMINES at neutral pH 7. Thus it is called neutral protamine Hagedorn for inventor Hans Christian Hagedorn.
Entry Term(s): Insulin, NPH; Insulin, Protamine Zinc; Isophane Insulin, Regular; NPH Insulin; Neutral Protamine Hagedorn Insulin; Protamine Hagedorn Insulin
Pharm Action: Hypoglycemic Agents
CAS Type 1 Name: Insulin Isophane
Public MeSH Note: 2009; see INSULIN, NPH 2009-2011; see INSULIN, ISOPHANE 1963-2008; for INSULIN, PROTAMINE ZINC see INSULIN, LONG-ACTING 1966-2011
History Note: 2009 (1963); for INSULIN, PROTAMINE ZINC use INSULIN, LONG-ACTING 1966-2011
Entry Combination: antagonists & inhibitors:Insulin Antagonists
Date Established: 2009/01/01
Date of Entry: 1999/01/01
Revision Date: 2015/05/26

Entry Combination: antagonists & inhibitors:Insulin Antagonists
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0011436
Scope Note: An intermediate-acting INSULIN preparation with onset time of 2 hours and duration of 24 hours. It is produced by crystallizing ZINC-insulin-PROTAMINES at neutral pH 7. Thus it is called neutral protamine Hagedorn for inventor Hans Christian Hagedorn.
Terms: Insulin, Isophane Preferred Term
Term UI T021974
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1966); Insulin, NPH
Term UI T021975
Date08/01/1980
LexicalTag ACX
ThesaurusID UNK (19XX); NPH Insulin
Term UI T021976
Date08/30/1982
LexicalTag ACX
ThesaurusID UNK (19XX); Protamine Hagedorn Insulin
Term UI T021977
Date09/18/1984
LexicalTag EPO
ThesaurusID UNK (19XX); Isophane Insulin, Regular
Term UI T493763
Date05/15/2002
LexicalTag NON
ThesaurusID NLM (2003); Neutral Protamine Hagedorn Insulin
Term UI T706331
Date09/24/2007
LexicalTag NON
ThesaurusID NLM (2009)

Insulin, Isophane MeSH Descriptor Data 2025