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Keratins MeSH Descriptor Data 2023


MeSH Heading
Keratins
Tree Number(s)
D05.750.078.593.450
D12.776.220.475.450
D12.776.860.607
Unique ID
D007633
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D007633
Scope Note
A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
Entry Term(s)
Cytokeratin
Keratin
Keratin Associated Protein
Keratin-Associated Proteins
alpha-Keratin
Registry Number
68238-35-7
Related Numbers
9008-18-8
See Also
Intermediate Filaments
Keratinocytes
Public MeSH Note
2007; see KERATIN 1966-2006; KERATIN-ASSOCIATED PROTEINS was indexed under KERATIN 2000-2006, & under PROTEINS 1993-1999
History Note
2007(1966)
Date Established
2007/01/01
Date of Entry
1999/01/01
Revision Date
2022/04/07
Keratins Preferred
Keratin-Associated Proteins Narrower
alpha-Keratin Narrower
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