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Leukodystrophy, Metachromatic MeSH Descriptor Data 2021


MeSH Heading
Leukodystrophy, Metachromatic
Tree Number(s)
C10.228.140.163.100.362.550
C10.228.140.163.100.435.825.850.500
C10.228.140.695.625.550
C10.314.400.550
C16.320.565.189.362.550
C16.320.565.189.435.825.850.500
C16.320.565.398.641.803.925.500
C16.320.565.595.554.825.850.500
C18.452.132.100.362.550
C18.452.132.100.435.825.850.500
C18.452.584.687.803.925.500
C18.452.648.189.362.550
C18.452.648.189.435.825.850.500
C18.452.648.398.641.803.925.500
C18.452.648.595.554.825.850.500
Unique ID
D007966
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D007966
Scope Note
An autosomal recessive metabolic disease caused by a deficiency of CEREBROSIDE-SULFATASE leading to intralysosomal accumulation of cerebroside sulfate (SULFOGLYCOSPHINGOLIPIDS) in the nervous system and other organs. Pathological features include diffuse demyelination, and metachromatically-staining granules in many cell types such as the GLIAL CELLS. There are several allelic and nonallelic forms with a variety of neurological symptoms.
Entry Term(s)
ARSA Deficiency
Arylsulfatase A Deficiency
Arylsulfatase A Deficiency Disease
Cerebral sclerosis, Diffuse, Metachromatic Form
Cerebroside Sulfatase Deficiency
Cerebroside Sulphatase Deficiency Disease
Greenfield Disease
Greenfield's Disease
Leukodystrophy, Metachromatic, Adult
Leukodystrophy, Metachromatic, Juvenile
Metachromatic Leukodystrophy
Metachromatic Leukodystrophy, Adult
Metachromatic Leukodystrophy, Adult-Type
Metachromatic Leukodystrophy, Infant
Metachromatic Leukodystrophy, Infant-Type
Metachromatic Leukodystrophy, Juvenile
Metachromatic Leukodystrophy, Juvenile-Type
Metachromatic Leukodystrophy, Late Infantile
Metachromatic Leukoencephalopathy
Sulfatide Lipidosis
See Also
Cerebroside-Sulfatase
Public MeSH Note
1974
History Note
1974
Date Established
1974/01/01
Date of Entry
1999/01/01
Revision Date
2013/07/08
Leukodystrophy, Metachromatic Preferred
Leukodystrophy, Metachromatic, Adult Narrower
Metachromatic Leukodystrophy, Infant Narrower
Arylsulfatase A Deficiency Narrower
Leukodystrophy, Metachromatic, Juvenile Narrower
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