Leukodystrophy, Globoid Cell MeSH Descriptor Data 2025

MeSH Heading: Leukodystrophy, Globoid Cell
Tree Number(s): C10.228.140.163.100.362.500; C10.228.140.163.100.435.825.590; C10.228.140.695.625.500; C10.314.400.500; C16.320.565.189.362.500; C16.320.565.189.435.825.590; C16.320.565.398.641.803.585; C16.320.565.595.554.825.590; C18.452.132.100.362.500; C18.452.132.100.435.825.590; C18.452.584.563.641.803.585; C18.452.648.189.362.500; C18.452.648.189.435.825.590; C18.452.648.398.641.803.585; C18.452.648.595.554.825.590
Unique ID: D007965
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D007965
Scope Note: An autosomal recessive metabolic disorder caused by a deficiency of GALACTOSYLCERAMIDASE leading to intralysosomal accumulation of galactolipids such as GALACTOSYLCERAMIDES and PSYCHOSINE. It is characterized by demyelination associated with large multinucleated globoid cells, predominantly involving the white matter of the central nervous system. The loss of MYELIN disrupts normal conduction of nerve impulses.
Entry Term(s): Classic Globoid Cell Leukodystrophy; Diffuse Globoid Body Sclerosis; Early-Onset Globoid Cell Leukodystrophy; GALC Deficiency; Galactocerebrosidase Deficiency; Galactosylceramidase Deficiency Disease; Galactosylceramide Lipidosis; Galactosylceramide beta-Galactosidase Deficiency; Galactosylceramide-beta-Galactosidase Deficiency Disease; Galactosylcerebrosidase Deficiency; Galactosylsphingosine Lipidosis; Globoid Body Sclerosis, Diffuse; Globoid Cell Leukodystrophy; Globoid Cell Leukoencephalopathy; Globoid Leukodystrophy; Infantile Globoid Cell Leukodystrophy; Krabbe Disease; Krabbe Leukodystrophy; Krabbe's Disease; Krabbe's Leukodystrophy; Late-Onset Globoid Cell Leukodystrophy; Leukodystrophy, Globoid Cell, Classic; Leukodystrophy, Globoid Cell, Early-Onset; Leukodystrophy, Globoid Cell, Infantile; Leukodystrophy, Globoid Cell, Late-Onset; Psychosine Lipidosis
See Also: Galactosylceramidase
Public MeSH Note: 1974; see CEREBRAL SCLEROSIS, DIFFUSE 1963-1973; for LEUKODYSTROPHIES see CEREBRAL SCLEROSIS, DIFFUSE 1963-1973; for KRABBE DISEASE see KRABBE'S DISEASE 1974-1997
History Note: 1974(1963)
Date Established: 1974/01/01
Date of Entry: 1999/01/01
Revision Date: 2021/07/01

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Nervous System Diseases [C10]
- Central Nervous System Diseases [C10.228]
  - Brain Diseases [C10.228.140]
    - Brain Diseases, Metabolic [C10.228.140.163]
      - Brain Diseases, Metabolic, Inborn [C10.228.140.163.100]
        
        Hereditary Central Nervous System Demyelinating Diseases [C10.228.140.163.100.362]
        
        Adrenoleukodystrophy [C10.228.140.163.100.362.250]
        
        Alexander Disease [C10.228.140.163.100.362.312]
        
        Canavan Disease [C10.228.140.163.100.362.375]
        
        Leukodystrophy, Globoid Cell [C10.228.140.163.100.362.500]
        
        Leukodystrophy, Metachromatic [C10.228.140.163.100.362.550]
        
        Pelizaeus-Merzbacher Disease [C10.228.140.163.100.362.775]

Nervous System Diseases [C10]
- Central Nervous System Diseases [C10.228]
  - Brain Diseases [C10.228.140]
    - Brain Diseases, Metabolic [C10.228.140.163]
      - Brain Diseases, Metabolic, Inborn [C10.228.140.163.100]
        
        Lysosomal Storage Diseases, Nervous System [C10.228.140.163.100.435]
        
        Sphingolipidoses [C10.228.140.163.100.435.825]
        
        Fabry Disease [C10.228.140.163.100.435.825.200]
        
        Farber Lipogranulomatosis [C10.228.140.163.100.435.825.250]
        
        Gangliosidoses [C10.228.140.163.100.435.825.300]
        
        Gaucher Disease [C10.228.140.163.100.435.825.400]
        
        Leukodystrophy, Globoid Cell [C10.228.140.163.100.435.825.590]
        
        Niemann-Pick Diseases [C10.228.140.163.100.435.825.700]
        
        Sea-Blue Histiocyte Syndrome [C10.228.140.163.100.435.825.775]
        
        Sulfatidosis [C10.228.140.163.100.435.825.850]

Nervous System Diseases [C10]
- Central Nervous System Diseases [C10.228]
  - Brain Diseases [C10.228.140]
    - Leukoencephalopathies [C10.228.140.695]
      - Hereditary Central Nervous System Demyelinating Diseases [C10.228.140.695.625]
        
        Adrenoleukodystrophy [C10.228.140.695.625.250]
        
        Alexander Disease [C10.228.140.695.625.312]
        
        Canavan Disease [C10.228.140.695.625.375]
        
        Leukodystrophy, Globoid Cell [C10.228.140.695.625.500]
        
        Leukodystrophy, Metachromatic [C10.228.140.695.625.550]
        
        Pelizaeus-Merzbacher Disease [C10.228.140.695.625.775]

Nervous System Diseases [C10]
- Demyelinating Diseases [C10.314]
  - Hereditary Central Nervous System Demyelinating Diseases [C10.314.400]

Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
  - Metabolism, Inborn Errors [C16.320.565]
    - Brain Diseases, Metabolic, Inborn [C16.320.565.189]
      - Hereditary Central Nervous System Demyelinating Diseases [C16.320.565.189.362]
        
        Adrenoleukodystrophy [C16.320.565.189.362.250]
        
        Alexander Disease [C16.320.565.189.362.312]
        
        Canavan Disease [C16.320.565.189.362.375]
        
        Leukodystrophy, Globoid Cell [C16.320.565.189.362.500]
        
        Leukodystrophy, Metachromatic [C16.320.565.189.362.550]
        
        Pelizaeus-Merzbacher Disease [C16.320.565.189.362.775]

Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
  - Metabolism, Inborn Errors [C16.320.565]
    - Brain Diseases, Metabolic, Inborn [C16.320.565.189]
      - Lysosomal Storage Diseases, Nervous System [C16.320.565.189.435]
        
        Sphingolipidoses [C16.320.565.189.435.825]
        
        Fabry Disease [C16.320.565.189.435.825.200]
        
        Farber Lipogranulomatosis [C16.320.565.189.435.825.250]
        
        Gangliosidoses [C16.320.565.189.435.825.300]
        
        Gaucher Disease [C16.320.565.189.435.825.400]
        
        Leukodystrophy, Globoid Cell [C16.320.565.189.435.825.590]
        
        Niemann-Pick Diseases [C16.320.565.189.435.825.700]
        
        Sea-Blue Histiocyte Syndrome [C16.320.565.189.435.825.775]
        
        Sulfatidosis [C16.320.565.189.435.825.850]

Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
  - Metabolism, Inborn Errors [C16.320.565]
    - Lipid Metabolism, Inborn Errors [C16.320.565.398]
      - Lipidoses [C16.320.565.398.641]
        
        Sphingolipidoses [C16.320.565.398.641.803]
        
        Fabry Disease [C16.320.565.398.641.803.300]
        
        Farber Lipogranulomatosis [C16.320.565.398.641.803.325]
        
        Gangliosidoses [C16.320.565.398.641.803.350]
        
        Gaucher Disease [C16.320.565.398.641.803.441]
        
        Leukodystrophy, Globoid Cell [C16.320.565.398.641.803.585]
        
        Niemann-Pick Diseases [C16.320.565.398.641.803.730]
        
        Sea-Blue Histiocyte Syndrome [C16.320.565.398.641.803.850]
        
        Sulfatidosis [C16.320.565.398.641.803.925]

Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
  - Metabolism, Inborn Errors [C16.320.565]
    - Lysosomal Storage Diseases [C16.320.565.595]
      - Lysosomal Storage Diseases, Nervous System [C16.320.565.595.554]
        
        Sphingolipidoses [C16.320.565.595.554.825]
        
        Fabry Disease [C16.320.565.595.554.825.200]
        
        Farber Lipogranulomatosis [C16.320.565.595.554.825.250]
        
        Gangliosidoses [C16.320.565.595.554.825.300]
        
        Gaucher Disease [C16.320.565.595.554.825.400]
        
        Leukodystrophy, Globoid Cell [C16.320.565.595.554.825.590]
        
        Niemann-Pick Diseases [C16.320.565.595.554.825.700]
        
        Sea-Blue Histiocyte Syndrome [C16.320.565.595.554.825.775]
        
        Sulfatidosis [C16.320.565.595.554.825.850]

Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
  - Brain Diseases, Metabolic [C18.452.132]
    - Brain Diseases, Metabolic, Inborn [C18.452.132.100]
      - Hereditary Central Nervous System Demyelinating Diseases [C18.452.132.100.362]
        
        Adrenoleukodystrophy [C18.452.132.100.362.250]
        
        Alexander Disease [C18.452.132.100.362.312]
        
        Canavan Disease [C18.452.132.100.362.375]
        
        Leukodystrophy, Globoid Cell [C18.452.132.100.362.500]
        
        Leukodystrophy, Metachromatic [C18.452.132.100.362.550]
        
        Pelizaeus-Merzbacher Disease [C18.452.132.100.362.775]

Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
  - Brain Diseases, Metabolic [C18.452.132]
    - Brain Diseases, Metabolic, Inborn [C18.452.132.100]
      - Lysosomal Storage Diseases, Nervous System [C18.452.132.100.435]
        
        Sphingolipidoses [C18.452.132.100.435.825]
        
        Fabry Disease [C18.452.132.100.435.825.200]
        
        Farber Lipogranulomatosis [C18.452.132.100.435.825.250]
        
        Gangliosidoses [C18.452.132.100.435.825.300]
        
        Gaucher Disease [C18.452.132.100.435.825.400]
        
        Leukodystrophy, Globoid Cell [C18.452.132.100.435.825.590]
        
        Niemann-Pick Diseases [C18.452.132.100.435.825.700]
        
        Sea-Blue Histiocyte Syndrome [C18.452.132.100.435.825.775]
        
        Sulfatidosis [C18.452.132.100.435.825.850]

Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
  - Lipid Metabolism Disorders [C18.452.584]
    - Lipid Metabolism, Inborn Errors [C18.452.584.563]
      - Lipidoses [C18.452.584.563.641]
        
        Sphingolipidoses [C18.452.584.563.641.803]
        
        Fabry Disease [C18.452.584.563.641.803.300]
        
        Farber Lipogranulomatosis [C18.452.584.563.641.803.325]
        
        Gangliosidoses [C18.452.584.563.641.803.350]
        
        Gaucher Disease [C18.452.584.563.641.803.441]
        
        Leukodystrophy, Globoid Cell [C18.452.584.563.641.803.585]
        
        Niemann-Pick Diseases [C18.452.584.563.641.803.730]
        
        Sea-Blue Histiocyte Syndrome [C18.452.584.563.641.803.850]
        
        Sulfatidosis [C18.452.584.563.641.803.925]

Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
  - Metabolism, Inborn Errors [C18.452.648]
    - Brain Diseases, Metabolic, Inborn [C18.452.648.189]
      - Hereditary Central Nervous System Demyelinating Diseases [C18.452.648.189.362]
        
        Adrenoleukodystrophy [C18.452.648.189.362.250]
        
        Alexander Disease [C18.452.648.189.362.312]
        
        Canavan Disease [C18.452.648.189.362.375]
        
        Leukodystrophy, Globoid Cell [C18.452.648.189.362.500]
        
        Leukodystrophy, Metachromatic [C18.452.648.189.362.550]
        
        Pelizaeus-Merzbacher Disease [C18.452.648.189.362.775]

Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
  - Metabolism, Inborn Errors [C18.452.648]
    - Brain Diseases, Metabolic, Inborn [C18.452.648.189]
      - Lysosomal Storage Diseases, Nervous System [C18.452.648.189.435]
        
        Sphingolipidoses [C18.452.648.189.435.825]
        
        Fabry Disease [C18.452.648.189.435.825.200]
        
        Farber Lipogranulomatosis [C18.452.648.189.435.825.250]
        
        Gangliosidoses [C18.452.648.189.435.825.300]
        
        Gaucher Disease [C18.452.648.189.435.825.400]
        
        Leukodystrophy, Globoid Cell [C18.452.648.189.435.825.590]
        
        Niemann-Pick Diseases [C18.452.648.189.435.825.700]
        
        Sea-Blue Histiocyte Syndrome [C18.452.648.189.435.825.775]
        
        Sulfatidosis [C18.452.648.189.435.825.850]

Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
  - Metabolism, Inborn Errors [C18.452.648]
    - Lipid Metabolism, Inborn Errors [C18.452.648.398]
      - Lipidoses [C18.452.648.398.641]
        
        Sphingolipidoses [C18.452.648.398.641.803]
        
        Fabry Disease [C18.452.648.398.641.803.300]
        
        Farber Lipogranulomatosis [C18.452.648.398.641.803.325]
        
        Gangliosidoses [C18.452.648.398.641.803.350]
        
        Gaucher Disease [C18.452.648.398.641.803.441]
        
        Leukodystrophy, Globoid Cell [C18.452.648.398.641.803.585]
        
        Niemann-Pick Diseases [C18.452.648.398.641.803.730]
        
        Sea-Blue Histiocyte Syndrome [C18.452.648.398.641.803.850]
        
        Sulfatidosis [C18.452.648.398.641.803.925]

Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
  - Metabolism, Inborn Errors [C18.452.648]
    - Lysosomal Storage Diseases [C18.452.648.595]
      - Lysosomal Storage Diseases, Nervous System [C18.452.648.595.554]
        
        Sphingolipidoses [C18.452.648.595.554.825]
        
        Fabry Disease [C18.452.648.595.554.825.200]
        
        Farber Lipogranulomatosis [C18.452.648.595.554.825.250]
        
        Gangliosidoses [C18.452.648.595.554.825.300]
        
        Gaucher Disease [C18.452.648.595.554.825.400]
        
        Leukodystrophy, Globoid Cell [C18.452.648.595.554.825.590]
        
        Niemann-Pick Diseases [C18.452.648.595.554.825.700]
        
        Sea-Blue Histiocyte Syndrome [C18.452.648.595.554.825.775]
        
        Sulfatidosis [C18.452.648.595.554.825.850]

Leukodystrophy, Globoid Cell Preferred

Early-Onset Globoid Cell Leukodystrophy Narrower

Late-Onset Globoid Cell Leukodystrophy Narrower

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