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Leukoencephalopathy, Progressive Multifocal MeSH Descriptor Data 2025


MeSH Heading
Leukoencephalopathy, Progressive Multifocal
Tree Number(s)
C01.207.245.340.500
C01.207.399.750.500
C01.925.182.525.500
C01.925.256.721.500
C01.925.839.550
C10.228.140.430.520.750.500
C10.228.140.695.750
C10.228.228.245.340.500
C10.228.228.399.750.500
C10.314.450
C10.586.250.520.750.500
Unique ID
D007968
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D007968
Scope Note
An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7)
Entry Version
LEUKOENCEPH PROGRESSIVE MULTIFOCAL
Entry Term(s)
Encephalitis, JC Polyomavirus
JC Polyomavirus Encephalopathy
Progressive Multifocal Leukoencephalopathy
Previous Indexing
Demyelinating Diseases (1966-1970)
Public MeSH Note
1973
History Note
1973(1971)
Date Established
1973/01/01
Date of Entry
1999/01/01
Revision Date
2021/06/30
Leukoencephalopathy, Progressive Multifocal Preferred
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