MeSH Browser

MeSH Heading: Subacute Sclerosing Panencephalitis
Tree Number(s): C01.207.245.340.600; C01.207.399.750.600; C01.925.182.525.600; C01.925.782.580.600.500.500.800; C01.925.839.862; C10.228.140.430.520.750.600; C10.228.228.245.340.600; C10.228.228.399.750.600; C10.586.250.520.750.600
Unique ID: D013344
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D013344
Scope Note: A rare, slowly progressive encephalitis caused by chronic infection with the MEASLES VIRUS. The condition occurs primarily in children and young adults, approximately 2-8 years after the initial infection. A gradual decline in intellectual abilities and behavioral alterations are followed by progressive MYOCLONUS; MUSCLE SPASTICITY; SEIZURES; DEMENTIA; autonomic dysfunction; and ATAXIA. DEATH usually occurs 1-3 years after disease onset. Pathologic features include perivascular cuffing, eosinophilic cytoplasmic inclusions, neurophagia, and fibrous gliosis. It is caused by the SSPE virus, which is a defective variant of MEASLES VIRUS. (From Adams et al., Principles of Neurology, 6th ed, pp767-8)
Entry Version: SUBACUTE SCLEROSING PANENCEPH
Entry Term(s): Encephalitis, Inclusion Body, Measles; Inclusion Body Encephalitis, Measles; Leukoencephalitis, Subacute Sclerosing; Leukoencephalitis, Van Bogaert's; Measles Inclusion Body Encephalitis; Panencephalitis, Subacute Sclerosing; SSPE; Sclerosing Leukoencephalitis, Subacute; Sclerosing Panencephalitis, Subacute; Van Bogaert's Leukoencephalitis
Previous Indexing: Cerebral Sclerosis, Diffuse (1966-1970)
Public MeSH Note: 71; VAN BOGAERT'S LEUKOENCEPHALITIS was see under SUBACUTE SCLEROSING PANENCEPHALITIS 1971-78; was see under CEREBRAL SCLEROSIS, DIFFUSE 1963-70
Online Note: use SUBACUTE SCLEROSING PANENCEPHALITIS to search VAN BOGAERT'S LEUKOENCEPHALITIS 1971-78; use CEREBRAL SCLEROSIS, DIFFUSE 1966-70
History Note: 71; VAN BOGAERT'S LEUKOENCEPHALITIS was see under SUBACUTE SCLEROSING PANENCEPHALITIS 1971-78; was see under CEREBRAL SCLEROSIS, DIFFUSE 1963-70
Date Established: 1971/01/01
Date of Entry: 1999/01/01
Revision Date: 2021/06/30

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

congenital (CN)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

transmission (TM)

urine (UR)

veterinary (VE)

virology (VI)

Infections [C01]
- Central Nervous System Infections [C01.207]
  - Central Nervous System Viral Diseases [C01.207.245]
    - Encephalitis, Viral [C01.207.245.340]

Infections [C01]
- Central Nervous System Infections [C01.207]
  - Infectious Encephalitis [C01.207.399]
    - Encephalitis, Viral [C01.207.399.750]

Infections [C01]
- Virus Diseases [C01.925]
  - Central Nervous System Viral Diseases [C01.925.182]
    - Encephalitis, Viral [C01.925.182.525]

Infections [C01]
- Virus Diseases [C01.925]
  - RNA Virus Infections [C01.925.782]
    - Mononegavirales Infections [C01.925.782.580]
      - Paramyxoviridae Infections [C01.925.782.580.600]
        
        Morbillivirus Infections [C01.925.782.580.600.500]
        
        Measles [C01.925.782.580.600.500.500]
        
        Subacute Sclerosing Panencephalitis [C01.925.782.580.600.500.500.800]

Infections [C01]
- Virus Diseases [C01.925]
  - Slow Virus Diseases [C01.925.839]

Nervous System Diseases [C10]
- Central Nervous System Diseases [C10.228]
  - Brain Diseases [C10.228.140]
    - Encephalitis [C10.228.140.430]
      - Infectious Encephalitis [C10.228.140.430.520]
        
        Encephalitis, Viral [C10.228.140.430.520.750]
        
        Encephalitis, Arbovirus [C10.228.140.430.520.750.300]
        
        Encephalitis, Herpes Simplex [C10.228.140.430.520.750.350]
        
        Encephalitis, Varicella Zoster [C10.228.140.430.520.750.400]
        
        Encephalomyelitis, Equine [C10.228.140.430.520.750.450]
        
        Leukoencephalopathy, Progressive Multifocal [C10.228.140.430.520.750.500]
        
        Subacute Sclerosing Panencephalitis [C10.228.140.430.520.750.600]

Nervous System Diseases [C10]
- Central Nervous System Diseases [C10.228]
  - Central Nervous System Infections [C10.228.228]
    - Central Nervous System Viral Diseases [C10.228.228.245]
      - Encephalitis, Viral [C10.228.228.245.340]
        
        Encephalitis, Arbovirus [C10.228.228.245.340.300]
        
        Encephalitis, Herpes Simplex [C10.228.228.245.340.350]
        
        Encephalitis, Varicella Zoster [C10.228.228.245.340.400]
        
        Encephalomyelitis, Equine [C10.228.228.245.340.450]
        
        Leukoencephalopathy, Progressive Multifocal [C10.228.228.245.340.500]
        
        Subacute Sclerosing Panencephalitis [C10.228.228.245.340.600]

Nervous System Diseases [C10]
- Central Nervous System Diseases [C10.228]
  - Central Nervous System Infections [C10.228.228]
    - Infectious Encephalitis [C10.228.228.399]
      - Encephalitis, Viral [C10.228.228.399.750]
        
        Encephalitis, Arbovirus [C10.228.228.399.750.300]
        
        Encephalitis, Herpes Simplex [C10.228.228.399.750.350]
        
        Encephalitis, Varicella Zoster [C10.228.228.399.750.400]
        
        Encephalomyelitis, Equine [C10.228.228.399.750.450]
        
        Leukoencephalopathy, Progressive Multifocal [C10.228.228.399.750.500]
        
        Subacute Sclerosing Panencephalitis [C10.228.228.399.750.600]

Nervous System Diseases [C10]
- Neuroinflammatory Diseases [C10.586]
  - Encephalitis [C10.586.250]
    - Infectious Encephalitis [C10.586.250.520]
      - Encephalitis, Viral [C10.586.250.520.750]
        
        Encephalitis, Arbovirus [C10.586.250.520.750.300]
        
        Encephalitis, Herpes Simplex [C10.586.250.520.750.350]
        
        Encephalitis, Varicella Zoster [C10.586.250.520.750.400]
        
        Encephalomyelitis, Equine [C10.586.250.520.750.450]
        
        Leukoencephalopathy, Progressive Multifocal [C10.586.250.520.750.500]
        
        Subacute Sclerosing Panencephalitis [C10.586.250.520.750.600]

Subacute Sclerosing Panencephalitis Preferred

Concept UI: M0020645
Scope Note: A rare, slowly progressive encephalitis caused by chronic infection with the MEASLES VIRUS. The condition occurs primarily in children and young adults, approximately 2-8 years after the initial infection. A gradual decline in intellectual abilities and behavioral alterations are followed by progressive MYOCLONUS; MUSCLE SPASTICITY; SEIZURES; DEMENTIA; autonomic dysfunction; and ATAXIA. DEATH usually occurs 1-3 years after disease onset. Pathologic features include perivascular cuffing, eosinophilic cytoplasmic inclusions, neurophagia, and fibrous gliosis. It is caused by the SSPE virus, which is a defective variant of MEASLES VIRUS. (From Adams et al., Principles of Neurology, 6th ed, pp767-8)
Terms: Subacute Sclerosing Panencephalitis Preferred Term
Term UI T039183
Date01/01/1999
LexicalTag NON
ThesaurusID; Sclerosing Panencephalitis, Subacute
Term UI T039181
Date02/10/1994
LexicalTag NON
ThesaurusID NLM (1995); Panencephalitis, Subacute Sclerosing
Term UI T039182
Date11/12/1991
LexicalTag NON
ThesaurusID; Leukoencephalitis, Van Bogaert's
Term UI T039184
Date02/10/1994
LexicalTag EPO
ThesaurusID NLM (1995); Van Bogaert's Leukoencephalitis
Term UI T039185
Date05/22/1978
LexicalTag EPO
ThesaurusID UNK (19XX); Sclerosing Leukoencephalitis, Subacute
Term UI T039186
Date02/10/1994
LexicalTag NON
ThesaurusID NLM (1995); Leukoencephalitis, Subacute Sclerosing
Term UI T039187
Date05/02/1992
LexicalTag NON
ThesaurusID NLM (1993); Measles Inclusion Body Encephalitis
Term UI T370626
Date11/03/1999
LexicalTag NON
ThesaurusID NLM (2000); Inclusion Body Encephalitis, Measles
Term UI T370628
Date11/03/1999
LexicalTag NON
ThesaurusID NLM (2000); Encephalitis, Inclusion Body, Measles
Term UI T000961140
Date06/18/2019
LexicalTag NON
ThesaurusID NLM (2020); SSPE
Term UI T039180
Date05/12/1989
LexicalTag ABB
ThesaurusID

Subacute Sclerosing Panencephalitis MeSH Descriptor Data 2025