MeSH Browser

MeSH Heading: alpha-Mannosidosis
Tree Number(s): C16.320.565.202.607.500; C16.320.565.595.577.500; C18.452.648.202.607.500; C18.452.648.595.577.500
Unique ID: D008363
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D008363
Scope Note: An inborn error of metabolism marked by a defect in the lysosomal isoform of ALPHA-MANNOSIDASE activity that results in lysosomal accumulation of mannose-rich intermediate metabolites. Virtually all patients have psychomotor retardation, facial coarsening, and some degree of dysostosis multiplex. It is thought to be an autosomal recessive disorder.
Entry Term(s): Alpha-D-Mannosidosis; Alpha-Mannosidase B Deficiency; Alpha-Mannosidosis, Type I; Lysosomal Alpha B Mannosidosis; Lysosomal alpha-D-Mannosidase Deficiency; Mannosidosis, alpha B Lysosomal; Mannosidosis, alpha B, Lysosomal; alpha Mannosidase B Deficiency; alpha-Mannosidase Deficiency
Previous Indexing: Carbohydrate Metabolism, Inborn Errors (1966-1984); Mannose (1966-1984); Mannosidases (1975-1984); Mannosidosis (1985-2003); Metabolism, Inborn Errors (1966-1984)
See Also: alpha-Mannosidase
Public MeSH Note: 2004; see MANNOSIDOSIS 1984-2003
History Note: 2004(1985)
Date Established: 1985/01/01
Date of Entry: 1984/05/29
Revision Date: 2013/07/08

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
  - Metabolism, Inborn Errors [C16.320.565]
    - Carbohydrate Metabolism, Inborn Errors [C16.320.565.202]
      - Mannosidase Deficiency Diseases [C16.320.565.202.607]
        
        alpha-Mannosidosis [C16.320.565.202.607.500]
        
        beta-Mannosidosis [C16.320.565.202.607.750]

Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
  - Metabolism, Inborn Errors [C16.320.565]
    - Lysosomal Storage Diseases [C16.320.565.595]
      - Mannosidase Deficiency Diseases [C16.320.565.595.577]
        
        alpha-Mannosidosis [C16.320.565.595.577.500]
        
        beta-Mannosidosis [C16.320.565.595.577.750]

Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
  - Metabolism, Inborn Errors [C18.452.648]
    - Carbohydrate Metabolism, Inborn Errors [C18.452.648.202]
      - Mannosidase Deficiency Diseases [C18.452.648.202.607]
        
        alpha-Mannosidosis [C18.452.648.202.607.500]
        
        beta-Mannosidosis [C18.452.648.202.607.750]

Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
  - Metabolism, Inborn Errors [C18.452.648]
    - Lysosomal Storage Diseases [C18.452.648.595]
      - Mannosidase Deficiency Diseases [C18.452.648.595.577]
        
        alpha-Mannosidosis [C18.452.648.595.577.500]
        
        beta-Mannosidosis [C18.452.648.595.577.750]

alpha-Mannosidosis Preferred

Concept UI: M0013006
Scope Note: An inborn error of metabolism marked by a defect in the lysosomal isoform of ALPHA-MANNOSIDASE activity that results in lysosomal accumulation of mannose-rich intermediate metabolites. Virtually all patients have psychomotor retardation, facial coarsening, and some degree of dysostosis multiplex. It is thought to be an autosomal recessive disorder.
Terms: alpha-Mannosidosis Preferred Term
Term UI T534637
Date03/06/2003
LexicalTag NON
ThesaurusID; alpha Mannosidase B Deficiency
Term UI T751402
Date05/18/2009
LexicalTag NON
ThesaurusID; Alpha-Mannosidase B Deficiency
Term UI T811735
Date11/15/2011
LexicalTag NON
ThesaurusID; alpha-Mannosidase Deficiency
Term UI T534705
Date03/07/2003
LexicalTag NON
ThesaurusID; Alpha-Mannosidosis, Type I
Term UI T811736
Date11/15/2011
LexicalTag NON
ThesaurusID OMIM (2013); Lysosomal alpha-D-Mannosidase Deficiency
Term UI T751403
Date05/18/2009
LexicalTag NON
ThesaurusID; Mannosidosis, alpha B Lysosomal
Term UI T751318
Date05/15/2009
LexicalTag NON
ThesaurusID; Mannosidosis, alpha B, Lysosomal
Term UI T534621
Date03/06/2003
LexicalTag NON
ThesaurusID; Alpha-D-Mannosidosis
Term UI T840864
Date04/18/2013
LexicalTag NON
ThesaurusID GHR (2014); Lysosomal Alpha B Mannosidosis
Term UI T840865
Date04/18/2013
LexicalTag NON
ThesaurusID GHR (2014)

alpha-Mannosidosis MeSH Descriptor Data 2025