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alpha-Mannosidase MeSH Descriptor Data 2023


MeSH Heading
alpha-Mannosidase
Tree Number(s)
D08.811.277.450.625.500
Unique ID
D043323
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D043323
Annotation
/DEFIC: consider also ALPHA-MANNOSIDOSIS
Scope Note
An enzyme that catalyzes the HYDROLYSIS of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. The enzyme plays a role in the processing of newly formed N-glycans and in degradation of mature GLYCOPROTEINS. There are multiple isoforms of alpha-mannosidase, each having its own specific cellular location and pH optimum. Defects in the lysosomal form of the enzyme results in a buildup of mannoside intermediate metabolites and the disease ALPHA-MANNOSIDOSIS.
Entry Term(s)
LAMAN
Lysosomal alpha-Mannosidase
Neutral alpha-Mannosidase
alpha Mannosidase B
alpha-D-Mannosidase
alpha-D-Mannoside Mannohydrolase
Registry Number
EC 3.2.1.24
Related Numbers
EC 3.2.1.24
Previous Indexing
Mannosidases (1980-2003)
See Also
alpha-Mannosidosis
Public MeSH Note
2004; ALPHA-MANNOSIDASE was indexed under MANNOSIDASES 1980-2003
History Note
2004; use ALPHA-MANNOSIDASE (NM) 1980-2003
Date Established
2004/01/01
Date of Entry
2003/07/09
alpha-Mannosidase Preferred
Lysosomal alpha-Mannosidase Narrower
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