MeSH Browser

MeSH Heading: beta-Mannosidase
Tree Number(s): D08.811.277.450.625.750
Unique ID: D044902
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D044902
Annotation: /defic: consider also BETA-MANNOSIDOSIS
Scope Note: An enzyme that catalyzes the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides. The enzyme plays a role in the lysosomal degradation of the N-glycosylprotein glycans. Defects in the lysosomal form of the enzyme in humans result in a buildup of mannoside intermediate metabolites and the disease BETA-MANNOSIDOSIS.
Entry Term(s): beta-D-Mannosidase; beta-Mannanase; manA protein (beta-Mannosidase)
Registry Number: EC 3.2.1.25
Related Numbers: 9025-43-8
Previous Indexing: Mannosidases (1980-2003)
See Also: beta-Mannosidosis
Public MeSH Note: 2004; BETA-MANNOSIDASE was indexed under MANNOSIDASES 1980-2003
History Note: 2004; use BETA-MANNOSIDASE (NM) 1980-2003
Date Established: 2004/01/01
Date of Entry: 2003/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0086105
Registry Number: EC 3.2.1.25
Related Numbers: 9025-43-8
Scope Note: An enzyme that catalyzes the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides. The enzyme plays a role in the lysosomal degradation of the N-glycosylprotein glycans. Defects in the lysosomal form of the enzyme in humans result in a buildup of mannoside intermediate metabolites and the disease BETA-MANNOSIDOSIS.
Terms: beta-Mannosidase Preferred Term
Term UI T116105
LexicalTag NON
ThesaurusID NLM (2004); beta-Mannanase
Term UI T459386
Date08/29/2001
LexicalTag NON
ThesaurusID NLM (2004); manA protein (beta-Mannosidase)
Term UI T543149
Date06/13/2003
LexicalTag NON
ThesaurusID NLM (2004); beta-D-Mannosidase
Term UI T116108
LexicalTag NON
ThesaurusID NLM (2004)

beta-Mannosidase MeSH Descriptor Data 2023