MeSH Browser

MeSH Heading: Plicamycin
Tree Number(s): D02.455.426.559.847.562.050.650; D04.615.562.050.650; D09.408.051.059.650
Unique ID: D008926
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D008926
Scope Note: A tricyclic pentaglycosidic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA. It is used as a fluorescent dye and as an antineoplastic agent, especially in bone and testicular tumors. Plicamycin is also used to reduce hypercalcemia, especially that due to malignancies.
Entry Term(s): Aureolic Acid; Mithramycin; Mitramycin
Pharm Action: Calcium-Regulating Hormones and Agents
Antibiotics, Antineoplastic
Fluorescent Dyes
Protein Synthesis Inhibitors
Nucleic Acid Synthesis Inhibitors
Registry Number: NIJ123W41V
Related Numbers: 18378-89-7
CAS Type 1 Name: Mithramycin
NLM Classification #: QV 269
Previous Indexing: Antibiotics, Antineoplastic (1967-1970)
Public MeSH Note: 93; was MITHRAMYCIN 1973-92
Online Note: use PLICAMYCIN to search MITHRAMYCIN 1971-92 (as Prov 1971-72)
History Note: 93; was MITHRAMYCIN 1971-92 (Prov 1971-72)
Date Established: 1973/01/01
Date of Entry: 1999/01/01
Revision Date: 2018/05/22

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0013935
Registry Number: NIJ123W41V
Related Numbers: 18378-89-7
Scope Note: A tricyclic pentaglycosidic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA. It is used as a fluorescent dye and as an antineoplastic agent, especially in bone and testicular tumors. Plicamycin is also used to reduce hypercalcemia, especially that due to malignancies.
Terms: Plicamycin Preferred Term
Term UI T026681
Date01/01/1999
LexicalTag NON
ThesaurusID; Mithramycin
Term UI T026679
Date02/21/1992
LexicalTag NON
ThesaurusID NLM (1993); Mitramycin
Term UI T026680
Date05/23/1980
LexicalTag NON
ThesaurusID UNK (19XX); Aureolic Acid
Term UI T026678
Date05/23/1980
LexicalTag NON
ThesaurusID UNK (19XX)

Plicamycin MeSH Descriptor Data 2023