MeSH Browser

MeSH Heading: DNA-Directed RNA Polymerases
Tree Number(s): D08.811.913.696.445.735.270
Unique ID: D012321
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D012321
Annotation: general or unspecified; prefer specifics
Scope Note: Enzymes that catalyze DNA template-directed extension of the 3'-end of an RNA strand one nucleotide at a time. They can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesized. (From Enzyme Nomenclature, 1992).
Entry Term(s): DNA-Dependent RNA Polymerases; DNA-Directed RNA Polymerase; RNA Polymerase; RNA Polymerases; Transcriptase; Transcriptases
CAS Type 1 Name: Nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed)
NLM Classification #: QU 141
Previous Indexing: RNA Nucleotidyltransferases (1968-1972)
Public MeSH Note: 2003; see DNA-DIRECTED RNA POLYMERASE 1998-2002, see RNA POLYMERASES 1977-1997, see RNA POLYMERASE 1973-1976
History Note: 2003(1973)
Date Established: 1973/01/01
Date of Entry: 1999/01/01
Revision Date: 2003/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0019148
Scope Note: Enzymes that catalyze DNA template-directed extension of the 3'-end of an RNA strand one nucleotide at a time. They can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesized. (From Enzyme Nomenclature, 1992).
Terms: DNA-Directed RNA Polymerases Preferred Term
Term UI T473605
Date12/13/2001
LexicalTag ACX
ThesaurusID NLM (2003); DNA-Dependent RNA Polymerases
Term UI T036571
Date04/16/1976
LexicalTag ACX
ThesaurusID UNK (19XX); RNA Polymerase
Term UI T036572
Date05/05/1987
LexicalTag ACX
ThesaurusID NLM (1988); RNA Polymerases
Term UI T036573
Date05/22/1997
LexicalTag ACX
ThesaurusID NLM (1998); Transcriptases
Term UI T036574
Date04/16/1976
LexicalTag NON
ThesaurusID UNK (19XX); DNA-Directed RNA Polymerase
Term UI T036575
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1973)

DNA-Directed RNA Polymerases MeSH Descriptor Data 2025