MeSH Browser

MeSH Heading: Tretinoin
Tree Number(s): D02.455.326.271.665.202.495.818.500; D02.455.426.392.368.367.379.249.700.860.500; D02.455.849.131.495.818.800; D02.455.849.291.925.500; D23.767.261.700.780
Unique ID: D014212
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D014212
Scope Note: An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).
Entry Term(s): Retin-A; Retinoic Acid; Tretinoin Potassium Salt; Tretinoin Sodium Salt; Tretinoin Zinc Salt; Vesanoid; Vitamin A Acid; all-trans-Retinoic Acid; beta-all-trans-Retinoic Acid; trans-Retinoic Acid
Pharm Action: Antineoplastic Agents
Keratolytic Agents
Registry Number: 5688UTC01R
Related Numbers: 13497-05-7; 22232-80-0; 302-79-4; 75980-27-7
CAS Type 1 Name: Retinoic acid
Previous Indexing: Carotenoids (1969-1974); Vitamin A (1966-1974)
See Also: Receptors, Retinoic Acid
Public MeSH Note: 80; was see under VITAMIN A 1975-79
History Note: 80(75); was see under VITAMIN A 1975-79
Date Established: 1980/01/01
Date of Entry: 1974/11/11
Revision Date: 2020/06/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0021879
Registry Number: 5688UTC01R
Related Numbers: 13497-05-7; 22232-80-0; 302-79-4; 75980-27-7
Scope Note: An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).
Terms: Tretinoin Preferred Term
Term UI T041632
Date01/01/1999
LexicalTag NON
ThesaurusID; Retinoic Acid
Term UI T041630
Date11/11/1974
LexicalTag NON
ThesaurusID UNK (19XX); Vitamin A Acid
Term UI T041633
Date11/11/1974
LexicalTag NON
ThesaurusID UNK (19XX); all-trans-Retinoic Acid
Term UI T041629
Date06/03/1982
LexicalTag NON
ThesaurusID; trans-Retinoic Acid
Term UI T041631
Date10/14/1983
LexicalTag NON
ThesaurusID UNK (19XX)

Tretinoin MeSH Descriptor Data 2023