MeSH Browser

MeSH Heading: Meglutol
Tree Number(s): D02.241.081.337.351.550
Unique ID: D015093
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015093
Scope Note: An antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate limiting enzyme in the biosynthesis of cholesterol.
Entry Term(s): 3-Hydroxy-3-methylglutaric Acid; 3-Hydroxy-3-methylpentanedioic Acid; beta-Hydroxy-beta-Methylglutarate
Pharm Action: Anticholesteremic Agents
Hypolipidemic Agents
Enzyme Inhibitors
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Registry Number: CLA99KCD53
Related Numbers: 503-49-1
CAS Type 1 Name: Pentanedioic acid, 3-hydroxy-3-methyl-
Previous Indexing: Anticholesteremic Agents (1966-1979); Antilipemic Agents (1966-1972); Glutarates (1966-1979); Hydroxy Acids (1975-1979)
Public MeSH Note: 96; was 3-HYDROXY-3-METHYLGLUTARIC ACID 1980-95 (see under GLUTARATES 1980-90)
History Note: 96; was 3-HYDROXY-3-METHYLGLUTARIC ACID 1980-95 (see under GLUTARATES 1980-90)
Date Established: 1991/01/01
Date of Entry: 1979/05/23
Revision Date: 2013/07/08

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0023214
Registry Number: CLA99KCD53
Related Numbers: 503-49-1
Scope Note: An antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate limiting enzyme in the biosynthesis of cholesterol.
Terms: Meglutol Preferred Term
Term UI T044057
Date01/01/1999
LexicalTag NON
ThesaurusID; 3-Hydroxy-3-methylpentanedioic Acid
Term UI T044058
Date05/05/1997
LexicalTag NON
ThesaurusID NLM (1998); beta-Hydroxy-beta-Methylglutarate
Term UI T044056
Date11/29/1982
LexicalTag NON
ThesaurusID UNK (19XX); 3-Hydroxy-3-methylglutaric Acid
Term UI T044055
Date12/01/1994
LexicalTag NON
ThesaurusID

Meglutol MeSH Descriptor Data 2023