MeSH Browser

MeSH Heading: Lambert-Eaton Myasthenic Syndrome
Tree Number(s): C04.588.614.550.500.225; C04.730.856.490.225; C10.114.656.150; C10.574.781.588.225; C10.668.758.725.150; C20.111.258.500.150
Unique ID: D015624
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015624
Scope Note: An autoimmune disease characterized by weakness and fatigability of proximal muscles, particularly of the pelvic girdle, lower extremities, trunk, and shoulder girdle. There is relative sparing of extraocular and bulbar muscles. CARCINOMA, SMALL CELL of the lung is a frequently associated condition, although other malignancies and autoimmune diseases may be associated. Muscular weakness results from impaired impulse transmission at the NEUROMUSCULAR JUNCTION. Presynaptic calcium channel dysfunction leads to a reduced amount of acetylcholine being released in response to stimulation of the nerve. (From Adams et al., Principles of Neurology, 6th ed, pp 1471)
Entry Term(s): Eaton-Lambert Myasthenic Syndrome; Eaton-Lambert Syndrome; Lambert-Eaton Syndrome; Myasthenic Syndrome, Lambert-Eaton; Myasthenic-Myopathic Syndrome of Eaton-Lambert; Myasthenic-Myopathic Syndrome of Lambert-Eaton; Myopathic-Myasthenic Syndrome of Eaton-Lambert; Myopathic-Myasthenic Syndrome of Lambert-Eaton
Previous Indexing: Muscular Diseases (1967-1988); Myasthenia Gravis (1980-1989); Neuromuscular Diseases (1980-1989); Neuromuscular Junction (1980-1986)
Public MeSH Note: 1990
History Note: 1990
Date Established: 1990/01/01
Date of Entry: 1989/04/07
Revision Date: 2019/02/22

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

congenital (CN)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Neoplasms [C04]
- Neoplasms by Site [C04.588]
  - Nervous System Neoplasms [C04.588.614]
    - Paraneoplastic Syndromes, Nervous System [C04.588.614.550]
      - Myasthenia Gravis [C04.588.614.550.500]
        
        Lambert-Eaton Myasthenic Syndrome [C04.588.614.550.500.225]

Neoplasms [C04]
- Paraneoplastic Syndromes [C04.730]
  - Paraneoplastic Syndromes, Nervous System [C04.730.856]
    - Myasthenia Gravis [C04.730.856.490]
      - Lambert-Eaton Myasthenic Syndrome [C04.730.856.490.225]

Nervous System Diseases [C10]
- Autoimmune Diseases of the Nervous System [C10.114]
  - Myasthenia Gravis [C10.114.656]

Nervous System Diseases [C10]
- Neurodegenerative Diseases [C10.574]
  - Paraneoplastic Syndromes, Nervous System [C10.574.781]
    - Myasthenia Gravis [C10.574.781.588]
      - Lambert-Eaton Myasthenic Syndrome [C10.574.781.588.225]

Nervous System Diseases [C10]
- Neuromuscular Diseases [C10.668]
  - Neuromuscular Junction Diseases [C10.668.758]
    - Myasthenia Gravis [C10.668.758.725]

Immune System Diseases [C20]
- Autoimmune Diseases [C20.111]
  - Autoimmune Diseases of the Nervous System [C20.111.258]
    - Myasthenia Gravis [C20.111.258.500]

Lambert-Eaton Myasthenic Syndrome Preferred

Concept UI: M0023968
Scope Note: An autoimmune disease characterized by weakness and fatigability of proximal muscles, particularly of the pelvic girdle, lower extremities, trunk, and shoulder girdle. There is relative sparing of extraocular and bulbar muscles. CARCINOMA, SMALL CELL of the lung is a frequently associated condition, although other malignancies and autoimmune diseases may be associated. Muscular weakness results from impaired impulse transmission at the NEUROMUSCULAR JUNCTION. Presynaptic calcium channel dysfunction leads to a reduced amount of acetylcholine being released in response to stimulation of the nerve. (From Adams et al., Principles of Neurology, 6th ed, pp 1471)
Terms: Lambert-Eaton Myasthenic Syndrome Preferred Term
Term UI T046215
Date01/01/1999
LexicalTag EPO
ThesaurusID; Myopathic-Myasthenic Syndrome of Eaton-Lambert
Term UI T368376
Date11/03/1999
LexicalTag NON
ThesaurusID NLM (2000); Myopathic-Myasthenic Syndrome of Lambert-Eaton
Term UI T368377
Date11/03/1999
LexicalTag NON
ThesaurusID NLM (2000); Lambert-Eaton Syndrome
Term UI T046211
Date01/30/1989
LexicalTag EPO
ThesaurusID; Eaton-Lambert Syndrome
Term UI T046212
Date02/24/1989
LexicalTag EPO
ThesaurusID; Eaton-Lambert Myasthenic Syndrome
Term UI T046213
Date01/30/1989
LexicalTag EPO
ThesaurusID NLM (1990); Myasthenic Syndrome, Lambert-Eaton
Term UI T046214
Date02/17/1998
LexicalTag EPO
ThesaurusID NLM (1999); Myasthenic-Myopathic Syndrome of Lambert-Eaton
Term UI T368375
Date11/03/1999
LexicalTag NON
ThesaurusID; Myasthenic-Myopathic Syndrome of Eaton-Lambert
Term UI T368374
Date11/03/1999
LexicalTag EPO
ThesaurusID NLM (2000)

Lambert-Eaton Myasthenic Syndrome MeSH Descriptor Data 2025