MeSH Browser

MeSH Heading: Gene Products, nef
Tree Number(s): D12.776.964.775.362; D12.776.964.925.500
Unique ID: D015693
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015693
Scope Note: Products of the retroviral NEF GENE. They play a role as accessory proteins that influence the rate of viral infectivity and the destruction of the host immune system. nef gene products were originally found as factors that trans-suppress viral replication and function as negative regulators of transcription. nef stands for negative factor.
Entry Term(s): 3'-orf Protein; Gene Product, nef; nef Gene Products; nef Protein
Registry Number: 0
Previous Indexing: Retroviridae Proteins (1987-1989); Viral Proteins (1987-1988)
Public MeSH Note: 91; was see under VIRAL REGULATORY PROTEINS 1990
History Note: 91(90); was see under VIRAL REGULATORY PROTEINS 1990
Date Established: 1991/01/01
Date of Entry: 1989/10/20
Revision Date: 2007/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0024067
Registry Number: 0
Scope Note: Products of the retroviral NEF GENE. They play a role as accessory proteins that influence the rate of viral infectivity and the destruction of the host immune system. nef gene products were originally found as factors that trans-suppress viral replication and function as negative regulators of transcription. nef stands for negative factor.
Terms: Gene Products, nef Preferred Term
Term UI T046506
Date01/01/1999
LexicalTag ABX
ThesaurusID NLM (1990); Gene Product, nef
Term UI T046504
Date04/07/1989
LexicalTag ABX
ThesaurusID NLM (1990); nef Protein
Term UI T046509
Date05/14/1990
LexicalTag ABX
ThesaurusID NLM (1991); 3'-orf Protein
Term UI T046503
Date10/20/1989
LexicalTag ABX
ThesaurusID NLM (1991); nef Gene Products
Term UI T046505
Date05/18/1989
LexicalTag ABX
ThesaurusID NLM (1990)

Gene Products, nef MeSH Descriptor Data 2023