MeSH Browser

MeSH Heading: Keratoderma, Palmoplantar, Diffuse
Tree Number(s): C16.320.850.475.440; C17.800.428.435.440; C17.800.827.475.440
Unique ID: D015776
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015776
Annotation: do not confuse with KERATODERMA, PALMOPLANTAR
Scope Note: An autosomal dominant disorder characterized by a widely distributed, well-demarcated hyperkeratosis of the palms and soles. There is more than one genotypically distinct form, each of which is clinically similar but histologically distinguishable. Diffuse palmoplantar keratoderma is distinct from palmoplantar keratoderma (KERATODERMA, PALMOPLANTAR), as the former exhibits autosomal dominant inheritance and hyperhidrosis is frequently present.
Entry Term(s): Keratosis Palmaris et Plantaris Familiaris; Thost-Unna Syndrome; Tylosis; Unna-Thost Syndrome
Previous Indexing: Keratoderma, Palmoplantar (1974-1989); Keratosis (1966-1973)
Public MeSH Note: 90
History Note: 90
Date Established: 1990/01/01
Date of Entry: 1989/10/19
Revision Date: 2015/06/18

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

congenital (CN)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Concept UI: M0024171
Scope Note: An autosomal dominant disorder characterized by a widely distributed, well-demarcated hyperkeratosis of the palms and soles. There is more than one genotypically distinct form, each of which is clinically similar but histologically distinguishable. Diffuse palmoplantar keratoderma is distinct from palmoplantar keratoderma (KERATODERMA, PALMOPLANTAR), as the former exhibits autosomal dominant inheritance and hyperhidrosis is frequently present.
Terms: Keratoderma, Palmoplantar, Diffuse Preferred Term
Term UI T046794
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1990); Thost-Unna Syndrome
Term UI T046795
Date03/09/1989
LexicalTag EPO
ThesaurusID NLM (1990); Unna-Thost Syndrome
Term UI T046796
Date03/09/1989
LexicalTag EPO
ThesaurusID NLM (1990); Tylosis
Term UI T046797
Date03/09/1989
LexicalTag NON
ThesaurusID

Keratoderma, Palmoplantar, Diffuse MeSH Descriptor Data 2025