MeSH Browser

MeSH Heading: Granulocyte Colony-Stimulating Factor
Tree Number(s): D09.400.430.775.200; D12.644.276.374.410.240.350; D12.776.395.240.200; D12.776.467.374.410.240.350; D23.529.374.410.240.350
Unique ID: D016179
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D016179
Scope Note: A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.
Entry Version: GCSF
Entry Term(s): Colony-Stimulating Factor, Granulocyte; G-CSF; Myeloid Growth Factor
Registry Numbers: 143011-72-7
NLM Classification #: WH 200
Previous Indexing: Colony-Stimulating Factors (1976-1990)
See Also: Receptors, Granulocyte Colony-Stimulating Factor
Public MeSH Note: 91
History Note: 91
Date Established: 1991/01/01
Date of Entry: 1990/06/19
Revision Date: 2023/06/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0024696
Registry Numbers: 143011-72-7
Scope Note: A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.
Terms: Granulocyte Colony-Stimulating Factor Preferred Term
Term UI T048061
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1991); Colony-Stimulating Factor, Granulocyte
Term UI T001126820
Date11/17/2022
LexicalTag NON
ThesaurusID NLM (2024); Myeloid Growth Factor
Term UI T001125751
Date10/19/2022
LexicalTag NON
ThesaurusID NLM (2024); G-CSF
Term UI T048060
Date02/15/1990
LexicalTag ABB
ThesaurusID NLM (1991)

Granulocyte Colony-Stimulating Factor MeSH Descriptor Data 2025