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Primary Ovarian Insufficiency MeSH Descriptor Data 2021


MeSH Heading
Primary Ovarian Insufficiency
Tree Number(s)
C13.351.500.056.630.750
C19.391.630.750
Unique ID
D016649
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D016649
Scope Note
Cessation of ovarian function after MENARCHE but before the age of 40, without or with OVARIAN FOLLICLE depletion. It is characterized by the presence of OLIGOMENORRHEA or AMENORRHEA, elevated GONADOTROPINS, and low ESTRADIOL levels. It is a state of female HYPERGONADOTROPIC HYPOGONADISM. Etiologies include genetic defects, autoimmune processes, chemotherapy, radiation, and infections. The most commonly known genetic cause is the expansion of a CGG repeat to 55 to 199 copies in the 5' untranslated region in the X-linked FMR1 gene.
Entry Term(s)
FMR1-Related Primary Ovarian Insufficiency
Fragile X Premature Ovarian Failure
Fragile X-Associated Primary Ovarian Insufficiency
Gonadotropin-Resistant Ovary Syndrome
Hypergonadotropic Ovarian Failure, X-Linked
Ovarian Failure, Premature
Premature Ovarian Failure
Premature Ovarian Failure 1
Premature Ovarian Failure, X-Linked
Primary Ovarian Insufficiency, Fragile X-Associated
Resistant Ovary Syndrome
X-Linked Hypergonadotropic Ovarian Failure
Previous Indexing
Menopause, Premature (1975-1991)
Ovarian Diseases (1966-1991)
See Also
Menopause, Premature
Public MeSH Note
2011; see Ovarian Failure, Premature 1992-2010
History Note
2011(1992)
Date Established
1992/01/01
Date of Entry
1991/05/30
Revision Date
2019/07/05
Primary Ovarian Insufficiency Preferred
Gonadotropin-Resistant Ovary Syndrome Narrower
Hypergonadotropic Ovarian Failure, X-Linked Narrower
Fragile X-Associated Primary Ovarian Insufficiency Narrower
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