MeSH Browser

MeSH Heading: Primary Ovarian Insufficiency
Tree Number(s): C12.050.351.500.056.630.750; C12.100.250.056.630.750; C19.391.630.750
Unique ID: D016649
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D016649
Scope Note: Cessation of ovarian function after MENARCHE but before the age of 40, without or with OVARIAN FOLLICLE depletion. It is characterized by the presence of OLIGOMENORRHEA or AMENORRHEA, elevated GONADOTROPINS, and low ESTRADIOL levels. It is a state of female HYPERGONADOTROPIC HYPOGONADISM. Etiologies include genetic defects, autoimmune processes, chemotherapy, radiation, and infections. The most commonly known genetic cause is the expansion of a CGG repeat to 55 to 199 copies in the 5' untranslated region in the X-linked FMR1 gene.
Entry Term(s): FMR1-Related Primary Ovarian Insufficiency; Fragile X Premature Ovarian Failure; Fragile X-Associated Primary Ovarian Insufficiency; Gonadotropin-Resistant Ovary Syndrome; Hypergonadotropic Ovarian Failure, X-Linked; Ovarian Failure, Premature; Premature Ovarian Failure; Premature Ovarian Failure 1; Premature Ovarian Failure, X-Linked; Primary Ovarian Insufficiency, Fragile X-Associated; Resistant Ovary Syndrome; X-Linked Hypergonadotropic Ovarian Failure
Previous Indexing: Menopause, Premature (1975-1991); Ovarian Diseases (1966-1991)
See Also: Menopause, Premature
Public MeSH Note: 2011; see Ovarian Failure, Premature 1992-2010
History Note: 2011(1992)
Date Established: 1992/01/01
Date of Entry: 1991/05/30
Revision Date: 2021/06/30

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

congenital (CN)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Urogenital Diseases [C12]
- Female Urogenital Diseases and Pregnancy Complications [C12.050]
  - Female Urogenital Diseases [C12.050.351]
    - Genital Diseases, Female [C12.050.351.500]
      - Adnexal Diseases [C12.050.351.500.056]
        
        Ovarian Diseases [C12.050.351.500.056.630]
        
        Anovulation [C12.050.351.500.056.630.050]
        
        Menopause, Premature [C12.050.351.500.056.630.250]
        
        Oophoritis [C12.050.351.500.056.630.450]
        
        Ovarian Cysts [C12.050.351.500.056.630.580]
        
        Ovarian Hyperstimulation Syndrome [C12.050.351.500.056.630.642]
        
        Ovarian Neoplasms [C12.050.351.500.056.630.705]
        
        Ovarian Torsion [C12.050.351.500.056.630.728]
        
        Primary Ovarian Insufficiency [C12.050.351.500.056.630.750]

Urogenital Diseases [C12]
- Genital Diseases [C12.100]
  - Genital Diseases, Female [C12.100.250]
    - Adnexal Diseases [C12.100.250.056]
      - Ovarian Diseases [C12.100.250.056.630]
        
        Anovulation [C12.100.250.056.630.050]
        
        Menopause, Premature [C12.100.250.056.630.250]
        
        Oophoritis [C12.100.250.056.630.450]
        
        Ovarian Cysts [C12.100.250.056.630.580]
        
        Ovarian Hyperstimulation Syndrome [C12.100.250.056.630.642]
        
        Ovarian Neoplasms [C12.100.250.056.630.705]
        
        Ovarian Torsion [C12.100.250.056.630.728]
        
        Primary Ovarian Insufficiency [C12.100.250.056.630.750]

Endocrine System Diseases [C19]
- Gonadal Disorders [C19.391]
  - Ovarian Diseases [C19.391.630]

Primary Ovarian Insufficiency Preferred

Concept UI: M0025370
Scope Note: Cessation of ovarian function after MENARCHE but before the age of 40, without or with OVARIAN FOLLICLE depletion. It is characterized by the presence of OLIGOMENORRHEA or AMENORRHEA, elevated GONADOTROPINS, and low ESTRADIOL levels. It is a state of female HYPERGONADOTROPIC HYPOGONADISM. Etiologies include genetic defects, autoimmune processes, chemotherapy, radiation, and infections. The most commonly known genetic cause is the expansion of a CGG repeat to 55 to 199 copies in the 5' untranslated region in the X-linked FMR1 gene.
Terms: Primary Ovarian Insufficiency Preferred Term
Term UI T767285
Date03/15/2010
LexicalTag NON
ThesaurusID NLM (2011); Ovarian Failure, Premature
Term UI T049854
Date01/01/1999
LexicalTag NON
ThesaurusID; Premature Ovarian Failure
Term UI T608691
Date09/09/2004
LexicalTag NON
ThesaurusID NLM (2006)

Gonadotropin-Resistant Ovary Syndrome Narrower

Hypergonadotropic Ovarian Failure, X-Linked Narrower

Fragile X-Associated Primary Ovarian Insufficiency Narrower

Primary Ovarian Insufficiency MeSH Descriptor Data 2023