MeSH Browser

MeSH Heading: Leukocyte Common Antigens
Tree Number(s): D08.811.277.352.650.775.400.100.500; D12.776.476.564.400.100.500; D12.776.543.733.937.500
Unique ID: D017493
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D017493
Scope Note: High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain two FIBRONECTIN TYPE III DOMAINS and possess cytoplasmic protein tyrosine phosphatase activity, which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. Leukocyte common antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.
Entry Term(s): 2H4 Antigens; Antigens, CD45; B220 Antigen; B220 Antigens; CD45 Antigen; CD45 Antigens; CD45R Antigens; CD45R0 Antigens; CD45RA Antigens; CD45RB Antigens; CD45RCAntigens; CD45RO Antigens; L-CA Antigens; Leukocyte Common Antigen; Protein Tyrosine Phosphatase, Receptor Type, C; T200 Antigens
Previous Indexing: Antigens, CD (1989-1992); Antigens, Differentiation (1984-1991); Histocompatibility Antigens (1984-1992)
Public MeSH Note: 2018; see ANTIGENS, CD45 1993-2017 and CD45 ANTIGEN 1984-1992; CD45 ANTIGEN was indexed under ANTIGENS, CD 1989-92 and HISTOCOMPATIBILITY ANTIGENS & ANTIGENS, DIFFERENTIATION 1984-92; RT7 ANTIGEN was indexed under HISTOCOMPATIBILITY ANTIGENS 1983-92; B220 ANTIGEN was indexed under ANTIGENS, SURFACE 1990-95
History Note: 2018 (1993); for RT7 use HISTOCOMPATIBILITY ANTIGENS RT 1983-92; for B220 ANTIGEN use ANTIGENS, CD45 1990-95
Date Established: 1993/01/01
Date of Entry: 1992/05/13
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Esterases [D08.811.277.352]
      - Phosphoric Monoester Hydrolases [D08.811.277.352.650]
        
        Protein Tyrosine Phosphatases [D08.811.277.352.650.775]
        
        Receptor-Like Protein Tyrosine Phosphatases [D08.811.277.352.650.775.400]
        
        Receptor-Like Protein Tyrosine Phosphatases, Class 1 [D08.811.277.352.650.775.400.100]
        
        Leukocyte Common Antigens [D08.811.277.352.650.775.400.100.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Protein Tyrosine Phosphatases [D12.776.476.564]
      - Receptor-Like Protein Tyrosine Phosphatases [D12.776.476.564.400]
        
        Receptor-Like Protein Tyrosine Phosphatases, Class 1 [D12.776.476.564.400.100]
        
        Leukocyte Common Antigens [D12.776.476.564.400.100.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptor-Like Protein Tyrosine Phosphatases [D12.776.543.733]
      - Receptor-Like Protein Tyrosine Phosphatases, Class 1 [D12.776.543.733.937]
        
        Leukocyte Common Antigens [D12.776.543.733.937.500]

Leukocyte Common Antigens Preferred

Concept UI: M0026536
Scope Note: High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain two FIBRONECTIN TYPE III DOMAINS and possess cytoplasmic protein tyrosine phosphatase activity, which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. Leukocyte common antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.
Terms: Leukocyte Common Antigens Preferred Term
Term UI T052497
Date04/03/1992
LexicalTag NON
ThesaurusID NLM (1993); CD45 Antigen
Term UI T052491
Date04/20/1992
LexicalTag ABX
ThesaurusID NLM (1993); CD45 Antigens
Term UI T052492
Date04/03/1992
LexicalTag ABX
ThesaurusID NLM (1993); Antigens, CD45
Term UI T052493
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1993); Protein Tyrosine Phosphatase, Receptor Type, C
Term UI T690766
Date02/02/2007
LexicalTag NON
ThesaurusID NLM (2008); L-CA Antigens
Term UI T052495
Date04/03/1992
LexicalTag ABX
ThesaurusID NLM (1993); Leukocyte Common Antigen
Term UI T052496
Date04/03/1992
LexicalTag NON
ThesaurusID NLM (1993); T200 Antigens
Term UI T052494
Date04/03/1992
LexicalTag ABX
ThesaurusID NLM (1993)

B220 Antigens Narrower

CD45RA Antigens Narrower

CD45RB Antigens Narrower

CD45RO Antigens Related

CD45RCAntigens Narrower

Leukocyte Common Antigens MeSH Descriptor Data 2025