MeSH Browser

MeSH Heading: Antibodies, Bispecific
Tree Number(s): D12.776.124.486.485.114.125; D12.776.124.790.651.114.134; D12.776.377.715.548.114.134
Unique ID: D018033
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D018033
Annotation: do not coordinate with ANTIBODY FORMATION for /‌biosynthesis
Scope Note: Antibodies, often monoclonal, in which the two antigen-binding sites are specific for separate ANTIGENIC DETERMINANTS. They are artificial antibodies produced by chemical crosslinking, fusion of HYBRIDOMA cells, or by molecular genetic techniques. They function as the main mediators of targeted cellular cytotoxicity and have been shown to be efficient in the targeting of drugs, toxins, radiolabeled haptens, and effector cells to diseased tissue, primarily tumors.
Entry Term(s): Bifunctional Antibodies; Bispecific Antibodies; Bispecific Monoclonal Antibodies
Pharm Action: Immunologic Factors
Registry Numbers: 0
Previous Indexing: Antibodies (1985-1993); specific Antibodies (1985-1993)
See Also: Immunotoxins; Radioimmunotherapy
Public MeSH Note: 94
History Note: 94
Date Established: 1994/01/01
Date of Entry: 1993/06/04
Revision Date: 2010/06/25

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Immunoproteins [D12.776.124.486]
      - Immunoglobulins [D12.776.124.486.485]
        
        Antibodies [D12.776.124.486.485.114]
        
        Antibodies, Anti-Idiotypic [D12.776.124.486.485.114.071]
        
        Antibodies, Archaeal [D12.776.124.486.485.114.089]
        
        Antibodies, Bacterial [D12.776.124.486.485.114.107]
        
        Antibodies, Bispecific [D12.776.124.486.485.114.125]
        
        Antibodies, Blocking [D12.776.124.486.485.114.143]
        
        Antibodies, Catalytic [D12.776.124.486.485.114.167]
        
        Antibodies, Fungal [D12.776.124.486.485.114.179]
        
        Antibodies, Helminth [D12.776.124.486.485.114.185]
        
        Antibodies, Heterophile [D12.776.124.486.485.114.191]
        
        Antibodies, Immobilized [D12.776.124.486.485.114.207]
        
        Antibodies, Monoclonal [D12.776.124.486.485.114.224]
        
        Antibodies, Neoplasm [D12.776.124.486.485.114.240]
        
        Antibodies, Neutralizing [D12.776.124.486.485.114.244]
        
        Antibodies, Phospho-Specific [D12.776.124.486.485.114.248]
        
        Antibodies, Protozoan [D12.776.124.486.485.114.252]
        
        Antibodies, Viral [D12.776.124.486.485.114.254]
        
        Antigen-Antibody Complex [D12.776.124.486.485.114.257]
        
        Autoantibodies [D12.776.124.486.485.114.323]
        
        Immune Sera [D12.776.124.486.485.114.573]
        
        Immunoglobulin Allotypes [D12.776.124.486.485.114.606]
        
        Immunoglobulin Isotypes [D12.776.124.486.485.114.619]
        
        Immunoglobulins, Intravenous [D12.776.124.486.485.114.632]
        
        Insulin Antibodies [D12.776.124.486.485.114.656]
        
        Isoantibodies [D12.776.124.486.485.114.664]
        
        Oligoclonal Bands [D12.776.124.486.485.114.715]
        
        Plantibodies [D12.776.124.486.485.114.820]
        
        Precipitins [D12.776.124.486.485.114.837]
        
        Reagins [D12.776.124.486.485.114.890]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Serum Globulins [D12.776.124.790]
      - Immunoglobulins [D12.776.124.790.651]
        
        Antibodies [D12.776.124.790.651.114]
        
        Antibodies, Anti-Idiotypic [D12.776.124.790.651.114.071]
        
        Antibodies, Archaeal [D12.776.124.790.651.114.107]
        
        Antibodies, Bacterial [D12.776.124.790.651.114.125]
        
        Antibodies, Bispecific [D12.776.124.790.651.114.134]
        
        Antibodies, Blocking [D12.776.124.790.651.114.143]
        
        Antibodies, Catalytic [D12.776.124.790.651.114.167]
        
        Antibodies, Fungal [D12.776.124.790.651.114.179]
        
        Antibodies, Helminth [D12.776.124.790.651.114.185]
        
        Antibodies, Heterophile [D12.776.124.790.651.114.191]
        
        Antibodies, Immobilized [D12.776.124.790.651.114.207]
        
        Antibodies, Monoclonal [D12.776.124.790.651.114.224]
        
        Antibodies, Neoplasm [D12.776.124.790.651.114.240]
        
        Antibodies, Neutralizing [D12.776.124.790.651.114.244]
        
        Antibodies, Phospho-Specific [D12.776.124.790.651.114.248]
        
        Antibodies, Protozoan [D12.776.124.790.651.114.252]
        
        Antibodies, Viral [D12.776.124.790.651.114.254]
        
        Antigen-Antibody Complex [D12.776.124.790.651.114.257]
        
        Autoantibodies [D12.776.124.790.651.114.323]
        
        Immune Sera [D12.776.124.790.651.114.573]
        
        Immunoconjugates [D12.776.124.790.651.114.580]
        
        Immunoglobulin Allotypes [D12.776.124.790.651.114.606]
        
        Immunoglobulin Isotypes [D12.776.124.790.651.114.619]
        
        Immunoglobulins, Intravenous [D12.776.124.790.651.114.632]
        
        Insulin Antibodies [D12.776.124.790.651.114.656]
        
        Isoantibodies [D12.776.124.790.651.114.664]
        
        Oligoclonal Bands [D12.776.124.790.651.114.715]
        
        Plantibodies [D12.776.124.790.651.114.820]
        
        Precipitins [D12.776.124.790.651.114.837]
        
        Reagins [D12.776.124.790.651.114.890]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Globulins [D12.776.377]
    - Serum Globulins [D12.776.377.715]
      - Immunoglobulins [D12.776.377.715.548]
        
        Antibodies [D12.776.377.715.548.114]
        
        Antibodies, Anti-Idiotypic [D12.776.377.715.548.114.071]
        
        Antibodies, Archaeal [D12.776.377.715.548.114.107]
        
        Antibodies, Bacterial [D12.776.377.715.548.114.125]
        
        Antibodies, Bispecific [D12.776.377.715.548.114.134]
        
        Antibodies, Blocking [D12.776.377.715.548.114.143]
        
        Antibodies, Catalytic [D12.776.377.715.548.114.167]
        
        Antibodies, Fungal [D12.776.377.715.548.114.179]
        
        Antibodies, Helminth [D12.776.377.715.548.114.185]
        
        Antibodies, Heterophile [D12.776.377.715.548.114.191]
        
        Antibodies, Immobilized [D12.776.377.715.548.114.207]
        
        Antibodies, Monoclonal [D12.776.377.715.548.114.224]
        
        Antibodies, Neoplasm [D12.776.377.715.548.114.240]
        
        Antibodies, Neutralizing [D12.776.377.715.548.114.244]
        
        Antibodies, Phospho-Specific [D12.776.377.715.548.114.248]
        
        Antibodies, Protozoan [D12.776.377.715.548.114.252]
        
        Antibodies, Viral [D12.776.377.715.548.114.254]
        
        Antigen-Antibody Complex [D12.776.377.715.548.114.257]
        
        Autoantibodies [D12.776.377.715.548.114.323]
        
        Immune Sera [D12.776.377.715.548.114.573]
        
        Immunoconjugates [D12.776.377.715.548.114.580]
        
        Immunoglobulin Allotypes [D12.776.377.715.548.114.606]
        
        Immunoglobulin Isotypes [D12.776.377.715.548.114.619]
        
        Immunoglobulins, Intravenous [D12.776.377.715.548.114.632]
        
        Insulin Antibodies [D12.776.377.715.548.114.656]
        
        Isoantibodies [D12.776.377.715.548.114.664]
        
        Oligoclonal Bands [D12.776.377.715.548.114.715]
        
        Plantibodies [D12.776.377.715.548.114.820]
        
        Precipitins [D12.776.377.715.548.114.837]
        
        Reagins [D12.776.377.715.548.114.890]

Antibodies, Bispecific Preferred

Concept UI: M0027219
Registry Numbers: 0
Scope Note: Antibodies, often monoclonal, in which the two antigen-binding sites are specific for separate ANTIGENIC DETERMINANTS. They are artificial antibodies produced by chemical crosslinking, fusion of HYBRIDOMA cells, or by molecular genetic techniques. They function as the main mediators of targeted cellular cytotoxicity and have been shown to be efficient in the targeting of drugs, toxins, radiolabeled haptens, and effector cells to diseased tissue, primarily tumors.
Terms: Antibodies, Bispecific Preferred Term
Term UI T053921
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1994); Bifunctional Antibodies
Term UI T053919
Date12/23/1992
LexicalTag NON
ThesaurusID NLM (1994); Bispecific Antibodies
Term UI T053920
Date12/23/1992
LexicalTag NON
ThesaurusID NLM (1994)

Bispecific Monoclonal Antibodies Narrower

Antibodies, Bispecific MeSH Descriptor Data 2024