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Mice, Inbred CFTR MeSH Descriptor Data 2023


MeSH Heading
Mice, Inbred CFTR
Tree Number(s)
B01.050.050.199.520.520.445
B01.050.150.900.649.313.992.635.505.500.400.445
Unique ID
D018181
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D018181
Annotation
NIM with no qualifiers when experimental animal
Scope Note
A strain of mice widely studied as a model for cystic fibrosis. These mice are generated from embryonic stem cells in which the CFTR (cystic fibrosis transmembrane conductance regulator) gene is inactivated by gene targeting. As a result, all mice have one copy of this altered gene in all their tissues. Mice homozygous for the disrupted gene exhibit many features common to young cystic fibrosis patients, including failure to thrive, meconium ileus, and alteration of mucous and serous glands.
Entry Term(s)
Mice, CFTR
Mouse, CFTR
Mouse, Inbred CFTR
Previous Indexing
Mice (1992-1993)
Public MeSH Note
94
History Note
94
Date Established
1994/01/01
Date of Entry
1993/06/03
Revision Date
2020/09/02
Mice, Inbred CFTR Preferred
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