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Thyroid Hormone Resistance Syndrome MeSH Descriptor Data 2023


MeSH Heading
Thyroid Hormone Resistance Syndrome
Tree Number(s)
C19.874.410.500
Unique ID
D018382
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D018382
Annotation
differentiate from EUTHYROID SICK SYNDROME where a non-thyroid disease is also present
Scope Note
An inherited autosomal recessive trait, characterized by peripheral resistance to THYROID HORMONES and the resulting elevation in serum levels of THYROXINE and TRIIODOTHYRONINE. This syndrome is caused by mutations of gene THRB encoding the THYROID HORMONE RECEPTORS BETA in target cells. HYPOTHYROIDISM in these patients is partly overcome by the increased thyroid hormone levels.
Entry Term(s)
Generalized Resistance to Thyroid Hormone
Generalized Thyroid Hormone Resistance
Refetoff Syndrome
Refetoff-DeWind-DeGroot Syndrome
Thyroid Hormone Resistance
See Also
Euthyroid Sick Syndromes
Public MeSH Note
95
History Note
95
Date Established
1995/01/01
Date of Entry
1994/02/28
Revision Date
2019/07/05
Thyroid Hormone Resistance Syndrome Preferred
Generalized Resistance to Thyroid Hormone Related
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