MeSH Browser

MeSH Heading: Thyroid Hormone Resistance Syndrome
Tree Number(s): C19.874.410.500
Unique ID: D018382
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D018382
Annotation: differentiate from EUTHYROID SICK SYNDROME where a non-thyroid disease is also present
Scope Note: An inherited autosomal recessive trait, characterized by peripheral resistance to THYROID HORMONES and the resulting elevation in serum levels of THYROXINE and TRIIODOTHYRONINE. This syndrome is caused by mutations of gene THRB encoding the THYROID HORMONE RECEPTORS BETA in target cells. HYPOTHYROIDISM in these patients is partly overcome by the increased thyroid hormone levels.
Entry Term(s): Generalized Resistance to Thyroid Hormone; Generalized Thyroid Hormone Resistance; Refetoff Syndrome; Refetoff-DeWind-DeGroot Syndrome; Thyroid Hormone Resistance
See Also: Euthyroid Sick Syndromes
Public MeSH Note: 95
History Note: 95
Date Established: 1995/01/01
Date of Entry: 1994/02/28
Revision Date: 2019/07/05

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Concept UI: M0027608
Scope Note: An inherited autosomal recessive trait, characterized by peripheral resistance to THYROID HORMONES and the resulting elevation in serum levels of THYROXINE and TRIIODOTHYRONINE. This syndrome is caused by mutations of gene THRB encoding the THYROID HORMONE RECEPTORS BETA in target cells. HYPOTHYROIDISM in these patients is partly overcome by the increased thyroid hormone levels.
Terms: Thyroid Hormone Resistance Syndrome Preferred Term
Term UI T054812
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1995); Refetoff Syndrome
Term UI T054814
Date09/08/1993
LexicalTag EPO
ThesaurusID; Refetoff-DeWind-DeGroot Syndrome
Term UI T054810
Date09/08/1993
LexicalTag EPO
ThesaurusID NLM (1995)

Thyroid Hormone Resistance Syndrome MeSH Descriptor Data 2025