MeSH Browser

MeSH Heading: Protein S Deficiency
Tree Number(s): C15.378.100.800; C15.378.147.890; C15.378.925.800
Unique ID: D018455
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D018455
Scope Note: An autosomal dominant disorder showing decreased levels of plasma protein S antigen or activity, associated with venous thrombosis and pulmonary embolism. PROTEIN S is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated PROTEIN C (also a vitamin K-dependent protein), and the clinical manifestations of its deficiency are virtually identical to those of protein C deficiency. Treatment with heparin for acute thrombotic processes is usually followed by maintenance administration of coumarin drugs for the prevention of recurrent thrombosis. (From Harrison's Principles of Internal Medicine, 12th ed, p1511; Wintrobe's Clinical Hematology, 9th ed, p1523)
Entry Version: PROTEIN S DEFIC
Entry Term(s): Deficiency, Protein S; Hereditary Thrombophilia Due To Protein S Deficiency
Previous Indexing: Glycoproteins/deficiency (1984-1992); Protein S/deficiency (1993-1994)
Public MeSH Note: 95
History Note: 95
Date Established: 1995/01/01
Date of Entry: 1994/04/16
Revision Date: 2013/07/08

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

congenital (CN)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Concept UI: M0027690
Scope Note: An autosomal dominant disorder showing decreased levels of plasma protein S antigen or activity, associated with venous thrombosis and pulmonary embolism. PROTEIN S is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated PROTEIN C (also a vitamin K-dependent protein), and the clinical manifestations of its deficiency are virtually identical to those of protein C deficiency. Treatment with heparin for acute thrombotic processes is usually followed by maintenance administration of coumarin drugs for the prevention of recurrent thrombosis. (From Harrison's Principles of Internal Medicine, 12th ed, p1511; Wintrobe's Clinical Hematology, 9th ed, p1523)
Terms: Protein S Deficiency Preferred Term
Term UI T054988
Date01/01/1999
LexicalTag NON
ThesaurusID; Deficiency, Protein S
Term UI T054987
Date01/25/1994
LexicalTag NON
ThesaurusID NLM (1995); Hereditary Thrombophilia Due To Protein S Deficiency
Term UI T842345
Date04/18/2013
LexicalTag NON
ThesaurusID GHR (2014)

Protein S Deficiency MeSH Descriptor Data 2025