MeSH Browser

MeSH Heading: Dopamine Antagonists
Tree Number(s): D27.505.519.625.150.175; D27.505.696.577.150.175
Unique ID: D018492
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D018492
Scope Note: Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.
Entry Version: DOPAMINE ANTAG
Entry Term(s): Antagonists, Dopamine; Antagonists, Dopamine Receptor; Antagonists, Dopaminergic; Dopamine Antagonist; Dopamine Blocker; Dopamine Blockers; Dopamine Receptor Antagonist; Dopamine Receptor Antagonists; Dopaminergic Antagonist; Dopaminergic Antagonists
Previous Indexing: Dopamine/antagonists & inhibitors (1966-1994)
Public MeSH Note: 95
History Note: 95
Date Established: 1995/01/01
Date of Entry: 1994/06/01
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Chemical Actions and Uses [D27]
- Pharmacologic Actions [D27.505]
  - Molecular Mechanisms of Pharmacological Action [D27.505.519]
    - Neurotransmitter Agents [D27.505.519.625]
      - Dopamine Agents [D27.505.519.625.150]
        
        Dopamine Agonists [D27.505.519.625.150.151]
        
        Dopamine Antagonists [D27.505.519.625.150.175]
        
        Dopamine D2 Receptor Antagonists [D27.505.519.625.150.175.500]
        
        Dopamine Uptake Inhibitors [D27.505.519.625.150.800]

Chemical Actions and Uses [D27]
- Pharmacologic Actions [D27.505]
  - Physiological Effects of Drugs [D27.505.696]
    - Neurotransmitter Agents [D27.505.696.577]
      - Dopamine Agents [D27.505.696.577.150]
        
        Dopamine Agonists [D27.505.696.577.150.151]
        
        Dopamine Antagonists [D27.505.696.577.150.175]
        
        Dopamine D2 Receptor Antagonists [D27.505.696.577.150.175.500]
        
        Dopamine Uptake Inhibitors [D27.505.696.577.150.800]

Dopamine Antagonists Preferred

Concept UI: M0027734
Scope Note: Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.
Terms: Dopamine Antagonists Preferred Term
Term UI T055082
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1995); Dopamine Receptor Antagonists
Term UI T055084
Date11/23/1993
LexicalTag NON
ThesaurusID NLM (1995); Dopaminergic Antagonists
Term UI T055086
Date11/23/1993
LexicalTag NON
ThesaurusID NLM (1995); Antagonists, Dopamine
Term UI T055081
Date11/23/1993
LexicalTag NON
ThesaurusID NLM (1995); Antagonists, Dopamine Receptor
Term UI T055083
Date11/23/1993
LexicalTag NON
ThesaurusID NLM (1995); Antagonists, Dopaminergic
Term UI T055085
Date11/23/1993
LexicalTag NON
ThesaurusID NLM (1995); Dopamine Blockers
Term UI T694227
Date03/22/2007
LexicalTag NON
ThesaurusID NLM (2008); Dopamine Antagonist
Term UI T000997383
Date11/19/2019
LexicalTag NON
ThesaurusID NLM (2021); Dopamine Blocker
Term UI T000997384
Date11/19/2019
LexicalTag NON
ThesaurusID NLM (2021); Dopamine Receptor Antagonist
Term UI T000997385
Date11/19/2019
LexicalTag NON
ThesaurusID NLM (2021); Dopaminergic Antagonist
Term UI T000997387
Date11/19/2019
LexicalTag NON
ThesaurusID NLM (2021)

Dopamine Antagonists MeSH Descriptor Data 2025