MeSH Browser

MeSH Heading: PrPC Proteins
Tree Number(s): D12.776.785.340.500
Unique ID: D018621
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D018621
Annotation: PrPC stands for PRion Protein Cellular; do not confuse with PRPSC PROTEINS which are scrapie prion proteins
Scope Note: Normal cellular isoform of PRION PROTEINS encoded by a chromosomal gene and found in normal and scrapie-infected brain tissue, and other normal tissue. PrPC are protease-sensitive proteins whose function is unknown. Posttranslational modification of PrPC into PrPSC leads to infectivity.
Entry Version: PRPC
Entry Term(s): Cp 33-35; Cp33-35, Scrapie; PrP-sen; Scrapie Amyloid Precursor Protein
Registry Number: 0
Previous Indexing: Prions (1992-1994)
Public MeSH Note: 95; SCRAPIE AMYLOID PRECURSOR PROTEIN was indexed under PRIONS & PROTEIN PRECURSORS 1992-94 and under VIRAL PROTEINS 1989-91
Online Note: use PRPC PROTEINS (NM) to search SCRAPIE AMYLOID PRECURSOR PROTEIN 1989-94
History Note: 95; SCRAPIE AMYLOID PRECURSOR PROTEIN was NM 1989-94
Date Established: 1995/01/01
Date of Entry: 1994/04/16
Revision Date: 2016/06/13

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pathogenicity (PY)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0027910
Registry Number: 0
Scope Note: Normal cellular isoform of PRION PROTEINS encoded by a chromosomal gene and found in normal and scrapie-infected brain tissue, and other normal tissue. PrPC are protease-sensitive proteins whose function is unknown. Posttranslational modification of PrPC into PrPSC leads to infectivity.
Terms: PrPC Proteins Preferred Term
Term UI T055449
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1995); PrP-sen
Term UI T055446
Date12/21/1993
LexicalTag NON
ThesaurusID NLM (1995); Cp 33-35
Term UI T055448
Date12/21/1993
LexicalTag ABB
ThesaurusID NLM (1995); Scrapie Amyloid Precursor Protein
Term UI T055445
Date12/22/1993
LexicalTag NON
ThesaurusID NLM (1995); Cp33-35, Scrapie
Term UI T055447
Date02/03/1994
LexicalTag ABB
ThesaurusID NLM (1995)

PrPC Proteins MeSH Descriptor Data 2023