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Multiple Endocrine Neoplasia Type 2a MeSH Descriptor Data 2022


MeSH Heading
Multiple Endocrine Neoplasia Type 2a
Tree Number(s)
C04.588.322.400.505
C04.651.600.505
C04.700.630.505
C16.320.700.630.505
C19.344.400.505
Unique ID
D018813
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D018813
Annotation
coordinate IM with specific endocrine/neoplasm pre-coordinates (IM) + specific histological type (IM) if pertinent
Scope Note
A form of multiple endocrine neoplasia characterized by the presence of medullary carcinoma (CARCINOMA, MEDULLARY) of the THYROID GLAND, and usually with the co-occurrence of PHEOCHROMOCYTOMA, producing CALCITONIN and ADRENALINE, respectively. Less frequently, it can occur with hyperplasia or adenoma of the PARATHYROID GLANDS. This disease is due to gain-of-function mutations of the MEN2 gene on CHROMOSOME 10 (Locus: 10q11.2), also known as the RET proto-oncogene that encodes a RECEPTOR PROTEIN-TYROSINE KINASE. It is an autosomal dominant inherited disease.
Entry Version
MULTIPLE ENDOCRINE NEOPL TYPE 2A
Entry Term(s)
MEA 2a
MEA II
MEA IIa
MEN 2
MEN 2a
MEN II
MEN IIa
MEN-2A Syndrome
MEN2a
Multiple Endocrine Neoplasia Type 2
Multiple Endocrine Neoplasia, Type IIa
Multiple Endocrine Neoplasms Type 2a
Neoplasia, Multiple Endocrine Type 2a
Neoplasms, Multiple Endocrine Type 2a
Pheochromocytoma And Amyloid-Producing Medullary Thyroid Carcinoma
Sipple Syndrome
Previous Indexing
Multiple Endocrine Neoplasia (1966-1994)
Public MeSH Note
95; MEA II, MEN II, & SIPPLE SYNDROME were see NEOPLASMS, MULTIPLE ENDOCRINE 1983-94
Online Note
use MULTIPLE ENDOCRINE NEOPLASIA to search MEA II, MEN II, & SIPPLE SYNDROME 1983-94
History Note
95; MEA II, MEN II, & SIPPLE SYNDROME were see NEOPLASMS, MULTIPLE ENDOCRINE 1983-94
Date Established
1995/01/01
Date of Entry
1994/05/23
Revision Date
2012/07/03
Multiple Endocrine Neoplasia Type 2a Preferred
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