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Multiple Endocrine Neoplasia Type 2b MeSH Descriptor Data 2025


MeSH Heading
Multiple Endocrine Neoplasia Type 2b
Tree Number(s)
C04.588.322.400.510
C04.651.600.510
C04.700.630.510
C16.320.700.630.510
C19.344.400.510
Unique ID
D018814
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D018814
Annotation
coordinate IM with specific endocrine/neoplasm pre-coordinates (IM) + specific histological type (IM) if pertinent
Scope Note
Similar to MEN2A, it is also caused by mutations of the MEN2 gene, also known as the RET proto-oncogene. Its clinical symptoms include medullary carcinoma (CARCINOMA, MEDULLARY) of THYROID GLAND and PHEOCHROMOCYTOMA of ADRENAL MEDULLA (50%). Unlike MEN2a, MEN2b does not involve PARATHYROID NEOPLASMS. It can be distinguished from MEN2A by its neural abnormalities such as mucosal NEUROMAS on EYELIDS; LIP; and TONGUE, and ganglioneuromatosis of GASTROINTESTINAL TRACT leading to MEGACOLON. It is an autosomal dominant inherited disease.
Entry Version
MULTIPLE ENDOCRINE NEOPL TYPE 2B
Entry Term(s)
MEA 2b
MEA IIb
MEN 2b
MEN 3
MEN III
MEN IIb
MEN2b
Mucosal Neuroma Syndrome
Multiple Endocrine Neoplasia, Type 2b
Multiple Endocrine Neoplasia, Type IIb
Multiple Endocrine Neoplasms Type 2b
Neoplasia, Multiple Endocrine Type 2b
Neoplasms, Multiple Endocrine Type 2b
Neuromata, Mucosal, With Endocrine Tumors
Wagenmann-Froboese Syndrome
Previous Indexing
Multiple Endocrine Neoplasia (1975-1994)
Public MeSH Note
1995; MEA III & MEN III see NEOPLASMS, MULTIPLE ENDOCRINE 1983-1994
History Note
1995; MEA III & MEN III see NEOPLASMS, MULTIPLE ENDOCRINE 1983-1994
Date Established
1995/01/01
Date of Entry
1994/05/23
Revision Date
2012/07/03
Multiple Endocrine Neoplasia Type 2b Preferred
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